Compact Blue Laser Module for Biomedical Instruments

描述（由申请人提供）：我们建议开发一种低成本， 发射波长在460 nm和490 nm之间的微型蓝色激光器模块 在荧光成像系统中。目前，460-490 nm的光谱范围是 主要由气体激光器，特别是氩离子激光器覆盖。虽然气体 激光器已经建立了很多年，他们已经有几个 众所周知的缺点，例如它们的激光管的有限寿命、低的 整体效率，过度的空气冷却和相当高的噪音在输出 动力.本发明的紧凑型蓝色激光器模块的创新设计旨在 取代这些笨重而昂贵的气冷氩离子激光器， 目前在大多数生物医学仪器中使用。建议紧凑，高 上转换，混合固态蓝光激光器将基于腔内 直接倍频，也称为，二次谐波产生（SHG）， 近红外III-V半导体二极管激光器。一期将 展示了一个具有高上转换效率的试验板原型， 热管理效率高、噪音低、稳定性高。这些 微型激光模块将从根本上彻底改变 荧光成像仪器在生物医学应用中的应用， 设计紧凑、多功能、高性能的DNA芯片和蛋白质芯片 扫描仪、流式细胞仪、微量滴定板读数器和共聚焦显微镜。 拟议商业应用：不可用

DESCRIPTION (provided by applicant): We propose to develop a low-cost, miniature blue laser module emitting between 460 nm and 490 nm for applications in fluorescence imaging systems. Currently this 460-490 nm spectral range is mainly covered by gas lasers, in particular the Argon-ion lasers. Although gas lasers have been well-established for many years, they posses several well-known disadvantages such as limited lifetime of their laser tubes, low overall efficiency, excessive air cooling, and rather high noise in the output power. The present innovative design of a compact blue laser module is aimed to replace these bulky and expensive air-cooled Argon-ion lasers that are currently used in most biomedical instruments. The proposed compact, high up-conversion, hybrid solid-state blue laser will be based on intra-cavity direct frequency doubling, a.k.a., Second Harmonic Generation (SHG), of near-infrared Ill-V semiconductor diode lasers. Phase I will demonstrate a bread-board prototype that has high up-conversion efficiency, high efficiency in heat management, low noise, and high stability. These miniature laser modules will fundamentally revolutionize the development of fluorescence imaging instruments in biomedical applications, making it possible to device compact, versatile and high-performance DNA chip and protein chip scanners, flow cytometers, micro-titer plate readers, and confocal microscopes. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE