Digital Resolution Improvement of SLO Angiograms

描述（由申请人提供）：本项目的主要商业目标 研究是一个有利可图的软件产品，视网膜专家， 提供血管系统和其他结构的改进的2D分辨能力， 眼底，使用荧光染料与扫描激光检眼镜（SLO）。 这些染料是吲哚菁绿色（ICG），其是红外的，从而显示 深部结构，如脉络膜和视神经脉管系统，以及荧光素 （FITC），其在可见光光谱中，从而显示视网膜色素。 脉管系统（顶层）。我们看到单是SLO血管造影术就有一个有利可图的市场。 我们的专业知识和现有的销售渠道都在这个市场。一个同样大 传统的数字眼底照相存在市场。的重点 第2阶段项目将涉及SLO血管造影。这项工作将在以后应用，因为 那么，到数字眼底摄影和反射光SLO（如 海德堡视网膜断层扫描仪）。第二阶段研究的目标是 旨在完善和证明开启广泛医学研究的方法 临床客户群。具体目标是：（1）提高速度， 接近常规临床实践所需的执行时间;（2）确保 具有各种数据类型和条件的鲁棒性;（3）开发一个变体 提供子像素分辨率的方法。(4)展示A 医学研究和临床实用性，将激发广泛的兴趣， 从事医学研究的视网膜专家客户群， 临床实践 拟定商业应用： 该产品最初将是一个附加到SLO的几个制造商（海德堡， Rodenstock，LDT），并最终添加到数字眼底相机。 约有 每年新增1000个SLO研究中心（考虑所有模式）， 急剧增长。 价格大约是1000美元。

DESCRIPTION (provided by applicant): The primary commercial objective of this research is a profitable software product for retinal specialists that will provide improved 2D resolving power of vasculature and other structures in the fundus, using fluorescent dyes with the scanning laser ophthalmoscope (SLO). These dyes are indocyanine green (ICG), which is infrared and thereby displays deep structures such as choroidal and optic nerve vasculature, and fluorescein (FITC) which is in the visible light spectrum and thereby displays retinal vasculature (top layer). We see a profitable market in SLO angiography alone. Our expertise and existing sales channels are in this market. An equally large market exists in conventional digital fundus photography. The focus of this Phase 2 project will be on SLO angiography. The work will later be applied, as well, to digital fundus photography and the reflected light SLO (such as the Heidelberg Retinal Tomograph). The objectives of this Phase II research are aimed at refining and proving the methodology to open a broad medical-research and clinical customer base. The specific aims are to: (1) Improve the speed to approach execution times necessary for routine clinical practice; (2) Ensure robustness with a variety of data types and conditions; (3) Develop a variant of the method that provides subpixel resolving power. (4) Demonstrate both a medical-research and clinical utility that will excite the interest of a broad customer base of retinal-specialist customers who are in medical-research and clinical practice. PROPOSED COMMERCIAL APPLICATION: The product will initially be an add-on to SLO's from several manufactures (Heidelberg, Rodenstock, LDT) and eventually an add-on to digital fundus cameras. There are about 1000 new SLO sites per year, when all modalities are considered, and this number is growing dramatically. The price will be about $1000.