POLYMERS WITH STEP-WISE VARIABLE SURFACE COMPOSITION

描述(逐字摘自申请人摘要)：申请 生物材料科学到目前正在开发的设备将受益于 具有阶梯式可变表面的表征良好的聚合物的可用性 组成。表面化学组分的控制在以下方面具有实用价值 组织工程学，在传统医疗设备的制造中和在新的 聚合物的纳米技术应用。在阶段我们确认，虽然利率 较慢，聚合物共混物的平衡表面张力/组成是 在数量上与液体溶剂中的传统表面活性剂相似。能量 最小化驱动表面平衡，这取决于 界面，例如，空气对血液。第二阶段包括三个系列的准备工作 具有不同表面组成的聚合物共混物，每一种具有不同的 表面改性端基：有机硅、氟碳、聚环氧乙烷。 每一系列都将通过几种表面敏感方法来表征 包括和频产生光谱、XPS、AFM和表面 张力/润湿性。每个特色化的系列都将受到电池的影响 包括(竞争性)蛋白质在内的短期体外生物学试验 吸附和补体激活。有待检验的假设是 生物反应会随着表面化学的变化而单调变化 表面化学是由真正的表面敏感方法和 对以下聚合物表面重排动力学的认识 将空气平衡的表面浸入水中。 建议的商业应用：不可用

DESCRIPTION (Verbatim from the Applicant's Abstract): The application of biomaterials science to devices now in development would benefit from the availability of well-characterized polymers with step wise variable surface composition. Control of surface chemistry bulk composition has utility in tissue engineering, in fabrication of conventional medial devices and in new nanotechnology application of polymers. In Phase we confirmed that, while rates are slower, equilibrium surface tension/composition of polymer blends is quantitatively similar to conventional surfactants in liquid Solvents. Energy minimization drives surface equilibration, which depends on the nature of the interface, e.g., air vs. blood. Phase II involves preparation of three series of polymer blends with varying surface composition, each with a different surface modifying end group: silicone, fluorocarbon, polyethyleneoxide. Each series will be characterized by several surface-sensitive methods including Sum Frequency Generation Spectroscopy, XPS, AFM and surface tension/wettability. Each characterized series will be subjected to a battery of short-term in vitro biological tests including (competitive) protein adsorption and complement activation. The hypothesis to be testes is that biological response will vary monotonically with surface chemistry when the surface chemistry is determined by truly surface-sensitive methods and knowledge of the kinetics of polymer surface rearrangement following upon immersion of air-equilibrated surfaces into aqueous fluids. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE