VASCULAR MR IMAG USING HYPERPOLARIZ 3HE DUAL WALLED MICROSPHERES: ANGIOGRAPHY

豚鼠肺气肿弹性蛋白酶模型的建立 类似于全腺性肺气肿的病理，常见于人类。 我们建议在活体内同时使用质子和氦核磁共振来跟踪 肺气肿在该模型中从最早发展到最晚 疾病的各个阶段。质子成像将使我们能够定义 间隙变化和超极化氦将提供关于 远端空域的预期变化。我们将把这些结合起来 结构分析和肺功能评估以澄清 磁共振图像的生理学解释。

The elastase model of emphysema in the guinea pig results in pathology resembling panacinar emphysema seen in frequently humans. We propose to use both proton and helium MRI to follow, in vivo, the development of emphysema in this model from the earliest to the latest stages of the disease. Proton imaging will allow us to define the interstitial changes and hyperpolarized helium will provide data on the expected changes in the distal air spaces. We will combine these structural analyses with assessments of pulmonary function to clarify the physiologic interpretation of the MR images.