Core--Methodology /Biostatistics

描述(改编自研究人员摘要)：密歇根社会不平等、心理和身体跨学科中心(MICSIMB)将促进一个跨学科研究计划，寻求了解心理社会状态(信念、态度、情感状态、价值观和社会关系)、它们的决定因素、压力和压力的病理生理学标记之间的相互作用，在生理和精神障碍的发展中，在儿童发育和衰老过程中。调查人员重点关注健康方面的社会经济和种族不平等，以及以社区为基础的儿童和成人、男子和妇女以及少数族裔样本中的生命周期和社区决定因素。这些项目代表了新的、具有成本效益的和相互关联的研究：(1)儿童的身体、情绪和认知状况在多大程度上反映了父母的社会经济地位、收入轨迹、经济压力和社区特征的影响；(2)糖皮质激素和5-羟色胺能机制在心理社会状态、SES和心血管疾病过度风险之间的关联中的作用；(3)在多水平代表性社区样本中，利用社区因素的最新评估，广泛的心理属性、其前驱因素和健康后遗症之间的相互关系，以及相关的应激生物标记物；(4)使用反映50多年评估数据的数据，研究生命过程不同阶段的社会经济、生物和心理社会因素对心理社会健康、心血管风险因素、成年后亚临床和确诊的心血管疾病等一系列指标的贡献；以及(5)随机选择的有年幼子女的贫困妇女群体中，长期经济压力对健康和功能的影响，作为福利改革的一部分，这些妇女从密歇根州AFDC的角色转移到新的“工作福利”计划中。开发和使用新的方法和生物统计工具、职业发展和传播活动，再加上上述研究计划，将有助于进一步将MICSIMB建成一个主要的国际中心，研究身心健康、心血管疾病、老龄化和儿童发展。这将由一个由来自9个学科的21名经验丰富的研究人员组成的小组完成，他们将以共生的方式共同开展五个研究项目，并努力扩大可用于此类分析的方法学和生物统计工具。

DESCRIPTION (adapted from investigator's abstract): The Michigan Interdisciplinary Center on Social Inequalities, Mind, and Body (MICSIMB), will foster an interdisciplinary research program seeking to understand the interactions of psychosocial states (beliefs, attitudes, affective states, values, and social relationships), their determinants, stress, and pathophysiologic marker of stress, in the development of physical and mental disorders, in child development, and in aging. The investigators include a focus on socioeconomic and racial inequalities in health, and on lifecourse and community determinants in community-based samples of children and adults, men and women, and minorities. The projects represent novel, cost-effective, and interrelated investigations of: (1) the extent to which children's physical, emotional, and cognitive status reflect the influence of parental socioeconomic status, income trajectories economic stress, and community characteristics; (2) the role of glucocorticoid and serotonergic mechanisms in the associations between psychosocial states, SES, and excess risk for CVD; (3) the interrelations between a broad array of psychological attributes, their antecedents and health sequelae, and related biological markers of stress, within a multilevel representative community sample, utilizing state of the art assessment of community factors; (4) contributions of socioeconomic, biological, and psychosocial factors at different stages of the life course to a broad range of indicators of psychosocial well-being, cardiovascular risk factors, subclinical and diagnosed CVD in adulthood, using data reflecting over 50 years of assessments; and, (5) the impact of chronic economic stress, in situ, on health and function in a randomly selected cohort of poor women with young children who, as part of welfare reform, were moved from the AFDC roles in Michigan into a new "workfare" program. The development and utilization of new methodological and biostatistical tools, career development, and dissemination activities coupled with the above research program will help to further establish the MICSIMB as a major international center for the study of mind/body interactions and physical health and mental health, cardiovascular disease, aging, and child development. This will be accomplished by a team of 21 experienced researchers from nine disciplines who will come together in a symbiotic way on five research projects and efforts to expand the methodological and biostatistical tools available for such analyses.