Elf5 and antiestrogen resistance

对抗雌激素治疗的抵抗导致一半的乳腺癌死亡。我们最近发现（Plos Biol 2012）转录因子Elf5密切参与这一过程。这项资助将发展我们对涉及Elf5的转录和基因组事件的理解，这些事件导致抗雌激素抗性和转移，开发抗雌激素抗性的新模型，预测抗雌激素抗性的生物标志物以及预防抗雌激素抗性的新治疗靶点和策略。

Resistance to anti estrogen therapies causes half of breast cancer deaths. We have recently discovered (Plos Biol 2012) that the transcription factor Elf5 is intimately involved in this process. This grant will develop our understanding of the transcriptional and genomic events involving Elf5 that lead to antiestrogen resistance and metatstasis, to develop new models of antiestrogen resistance, biomarkers that predict antiestrogen resistance and new therapeutic targets and strategies that prevent antiestrogen resistance.