Clinical Radiation Physics Service

该科继续为放射治疗提供专家实物和技术支助，包括所有放射生产设备和辅助设备的例行校准、质量保证和一线维护。它包括专门的剂量测定研究、计算机辅助治疗计划、病人监测以及根据不断发展的临床需要设计和开发专门设备。二极管目前在临床上用于验证患者剂量，准确度为+/-3%。放射外科系统已安装并调试。到目前为止，我们已经成功治疗了25例立体定向放射外科患者，并计划利用植入式支架连接点从单次分割转移到多次分割放射外科。与海军研究实验室合作的项目正在顺利进行，以评估掺杂半导体的石英玻璃的临床用途。我们正在继续表征的剂量特性，并使用这些数据来完善探测器的发展。临床试验预计将于2000年10月初开始。微型多叶准直器（MMLC）已投入使用，不久将开始临床使用。正在进行的项目包括调试能够治疗更复杂肿瘤体积的精细立体定向治疗计划系统以及调强放射治疗（IMRT）的开发。新的记录和核查系统（IMPAC-ACCESS）已经交付和安装。我们现正与供应商商讨如何发展多媒体控制中心的界面。NCI IMRT研究计划的建立将包括无框架立体定向定位系统的开发。

The section continues to provide expert physical and technological support for radiation treatment, consisting of routine calibration, quality assurance and first-line maintenance of all radiation producing and ancillary equipment. It includes special dosimetry studies, computer- assisted treatment planning, patient monitoring and the design and development of special equipment tailored to developing clinical needs. Diodes are now in routine clinical use for the verification of patient doses and exhibit an accuracy of +/- 3%. The radiosurgery system has been installed and commissioned. To this date, we have successfully treated 25 stereotactic radiosurgery patients and plan to migrate from single fraction to multi fraction radiosurgery utilizing implantable frame attachment points. The project in collaboration with the Naval Research Laboratory to evaluate the clinical utility of semiconductor doped quartz glass is well under way. We are continuing the characterization of the dosimetric properties and using these data to refine detector development. Clinical trials are expected to start by early October, 2000. The mini multi-leaf collimator (MMLC) has been commissioned and clinical use will commence shortly. Ongoing projects are the commissioning of a refined stereotactic treatment planning system capable of treating more complex tumor volumes and on the development of intensity modulated radiation therapy (IMRT). The new Record-and-Verify system (IMPAC-ACCESS) has been delivered and installed. We are now in negotiation with the vendor on the development of the interface to the MMLC. The establishment of an IMRT research program at NCI will include the development of a frameless stereotactic localization system.