Elucidating the flexibility of coreceptor engagement by HIV-1 important for macrophage tropism and escape from entry inhibitors

CCR 5拮抗剂是一种新型的抗HIV-1药物，可以阻止病毒进入细胞。我们有证据表明，CCR 5拮抗剂正常发挥作用的能力与HIV-1感染一种称为巨噬细胞的免疫细胞的能力有关。在这项提案中，我们将精确研究HIV-1如何进入巨噬细胞，然后确定这如何影响接受这些药物作为临床护理一部分的患者的结果。

CCR5 antagonists are a new type of anti-HIV-1 drug that stops the virus from entering cells. We have evidence to suggest that the ability of CCR5 antagonists to function properly is linked to the ability of HIV-1 to infect a type of immune cell called macrophages. In this proposal, we will investigate precisely how HIV-1 enters macrophage cells, and then determine how this may influence the outcome of patients who are receiving these drugs as part of their clinical care.