EPIDEMIOLOGY OF NON HODGKINS'S LYMPHOMA DATA ANALYSIS

1988年至1995年，首席调查员及其同事在旧金山湾区进行了一项以人群为基础的非霍奇金淋巴瘤(NHL)病例对照研究，包括近1600名NHL患者和2500多名对照参与者。北加州癌症中心使用快速病例确认法获得NHL病例，对照参与者使用随机数字拨号和医疗融资管理局的文件进行识别。本研究对NHL患者的病理资料进行了回顾和分类，包括：1)评估在这项大型研究中收集的暴露数据与使用工作公式定义的NHL亚型之间的关联，重点是调查在所有NHL的主要分析中发现的重要风险因素；以及2)完成详细分析，以调查NHL风险与职业和化学暴露之间的关联，包括女性中的橙剂、生殖和激素暴露，支持假设，即不同NHL亚型之间存在病因差异，可以通过一组独特的相关风险因素来表征。根据非霍奇金淋巴瘤亚型区分风险因素将为详细分析非霍奇金淋巴瘤的利益暴露和风险之间的关系提供重要线索，并调整潜在的混杂因素和影响因素。这些数据可能解释了早期非霍奇金淋巴瘤研究结果不一致的原因，这些研究受到样本量和暴露数据的限制。它们还可能提供关于暴露改变Th1或Th2途径和淋巴肿大过程的重要补充信息。这些数据将被用作湾区更大规模的淋巴瘤研究的初步结果。

A population-based case-control study of non-Hodgkin's lymphoma (NHL) that included nearly 1600 patients with NHL and more than 2500 control participants was conducted by the Principal Investigator and colleagues in the San Francisco Bay Area between 1988 and 1995. NHL cases were obtained using rapid case ascertainment by the Northern California Cancer Center and control participants were identified using random digit dial and the Healthcare Financing Administration files. Pathology materials for the NHL patients included in the study were reviewed and classified of this study are: 1) to evaluate the association between exposure data collected in this large study and subtypes of NHL defined using the Working Formulation with emphasis on the investigation of risk factors found to be of importance in the main analyses of all NHL; and 2) to complete detailed analyses to investigate the association between risk for NHL and occupational and chemical exposures including Agent Orange, reproductive and hormonal exposures among women , support for hypotheses that indicated there are etiologic differences across NHL subtypes that can be characterized by a unique set of associated risk factors. Differentiation of risk factors by NHL subtypes will provide important clues to detailed analyses between exposures of interest and risk for NHL with adjustment for potential confounders and effect modifiers. These data may explain inconsistencies in results from earlier NHL studies constrained by limited sample size and exposure data. They also may provide important additional information about the role of exposures that alter Th1 or Th2 pathways and the process of lymphomagenesis. These data will be used as preliminary results for a larger Bay Area study of lymphoma.