REGULATION OF ENERGY PARTITIONING DURING WEIGHT CHANGE

领旅鼠能够加倍他们的体重和身体脂肪 内容响应于光周期的变化。这种情况发生时， 食物摄入量的变化。将使用光诱导的体重变化 检查能量消耗变化之间的时间关系， （休息和活动）和燃料分配。在这份修改后的申请中， 提示瘦素和皮质酮可能都起重要作用， 在体重和身体组成的季节性变化中的作用。是 假设在体重增加期间：1）静息能量减少 支出将与体重增加的早期阶段， 减少与体力活动相关的能量消耗， 与体重增加后的体重维持相关; 2）增加 代谢效率（解偶联蛋白mRNA表达降低） 会导致早期静息能量消耗减少 体重增加阶段; 3）光周期引起的体重下降 皮质酮浓度降低ob mRNA表达， 反过来会降低解偶联蛋白mRNA的表达。相反， 也可以在这个模型系统中进行失重研究。结果将 阐明了能量消耗和能量分配在 体重和身体组成的调节。基础科学 从这个模型中获得的信息应该有助于理解 代谢紊乱在人类肥胖病因学中的作用。

Collared lemmings are able to double their body weight and body fat content in response to a change in photoperiod. This occurs without a change in food intake. Photo-induced changes in body weight will be used to examine the temporal relationships among changes in energy expenditure (resting and activity) and fuel partitioning. In this revised application, it is proposed that both leptin and corticosterone may play important roles in the seasonal changes in body weight and body composition. It is hypothesized that during weight gain: 1) A decrease in resting energy expenditure will be associated with the early phase of weight gain, and a decrease in energy expenditure associated with physical activity will be associated with weight maintenance after weight gain; 2) increased metabolic efficiency (decreased expression of uncoupling protein mRNA) will cause the decrease in resting energy expenditure during the early phase of weight gain; 3) the photoperiod-induced decrease in corticosterone concentration will decrease ob mRNA expression, which in turn will decrease uncoupling protein mRNA expression. The converse will also be studied during weight loss in this model system. The results will shed light on the role of energy expenditure and energy partitioning on the regulation of body weight and body composition. The basic scientific information gained from this model should be useful for understanding the role of metabolic perturbations in the etiology of human obesity.