NIEHS Statistical Consulting Service

该项目的目标是为各种研究所的研究活动，包括实验室和人体研究，提供设计、分析和解释实验和观察研究的统计和计算专业知识。在2001财政年度，大约有80名科学家使用了统计咨询服务。其中许多活动涉及国家毒理学规划的长期啮齿动物致癌性研究。在2001财年，我们为编写大约12份国家结核控制规划技术报告提供了大量投入，这些报告总结了这些研究的结果。我们还在科学文献中共同撰写了一篇关于磁场致癌效应的论文。其他合作的例子包括(i)评估抗逆转录病毒疗法对艾滋病毒感染者淋巴细胞和精子的遗传和形态学终点的影响；（ii）研究在发育过程中暴露于己烯雌酚的雄性后代中增殖性病变和生殖道肿瘤的发生情况；（iii）评估砷、镉、铬和铅对重组HepG2细胞中13种不同启动子调控的基因表达的影响；（iv）设计和实施一项纵向研究，以评估300名育龄妇女子宫肌瘤的生长和发展。

The goal of this project is to provide statistical and computational expertise in the design, analysis, and interpretation of experimental and observational studies for a variety of Institute research activities, including both laboratory and human studies. Approximately 80 scientists made use of the Statistical Consulting Service in FY2001. Many of these activities involved NTP's long term rodent carcinogenicity studies. During FY2001 we provided significant input into the preparation of approximately 12 NTP Technical Reports that summarized the results of these studies. We also coauthored a paper in the scientific literature dealing with the carcinogenic effects of magnetic fields. Examples of other collaborations include (i) evaluating the effects of antiretroviral therapy on genetic and morphological endpoints in lymphocytes and sperm of people with HIV infection; (ii) investigating the occurrence of proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol; (iii) evaluating the effects of arsenic, cadmium, chromium, and lead on gene expression regulated by a battery of 13 different promoters in recombinant HepG2 cells; and (iv) designing and implementing a longitudinal study to evaluate the growth and development of uterine fibroids in 300 women of child bearing age.