Neuromodulation of auditory input

描述(申请者提供)：鸣鸟声乐学习提供 研究大脑和行为关系的优秀模型系统。 来自自由行为的鸟类的电生理数据表明，行为 状态与歌曲维护相关。听觉反馈，这是必要的 歌曲的维护，在功能上和功能上都有不同的规定 前脑歌唱系统在解剖学上的不同路径 行为状态。我们的建议旨在将体内和体外相结合 检测胆碱能特异性效应的电生理技术 听觉反馈在前脑核团传递中的输入 听觉和运动前活动的联系。胆碱能系统已被证明 与许多生物体的注意力、唤醒和记忆有关，包括 人类。因此，这一系列实验将有可能 说明反馈和注意机制在以下行为中的作用 复杂的运动行为。

DESCRIPTION (provided by applicant): Songbird vocal learning provides an excellent model system in which to study the relationship of brain and behavior. Electrophysiological data from freely behaving birds suggest that behavioral state is relevant to song maintenance. Auditory feedback, which is necessary for the maintenance of song, is differentially regulated in two functionally and anatomically distinct pathways of the forebrain song system according to behavioral state. Our proposal aims to combine in vivo and in vitro electrophysiological techniques to examine the specific effects of cholinergic input on the transmission of auditory feedback in a forebrain nucleus which is a nexus of auditory and premotor activity. Cholinergic systems have been shown to be related to attention, arousal, and memory in a number of organisms, including humans. This series of experiments will therefore have the potential to illuminate the role of feedback and attentional mechanisms in the performance of complex motor behaviors.