RESEARCH TRAINING IN PHYSIOLOGICAL ADAPTATION TO STRESS

描述：(申请人提供)在第一个资助期内，该项目名为《压力适应生理研究培训》的博士后培训项目吸引了优秀的学生，该项目的5名毕业生获得了一流的博士后职位或行业职位。目前，NIH资助的名额中有60%是少数族裔学生。基于这一成功，我们寻求在未来五年内继续支持该计划。对压力的生理适应包括一系列反应，从影响细胞新陈代谢的分子结构的改变到机体的重塑。适应可能是积极的，比如增加定期体力活动带来的适应，或者它们可能会有病理后遗症，比如对创伤的高代谢反应。我们的博士前培训计划利用了位于好时校区医学院和宾夕法尼亚州立大学大学园区几个系的现有的、国际公认的师资力量。正在进行的培训计划的目标是培养具有产生、整合和应用通过多种方法收集的知识来研究应激生理学的科学家的能力。该培训计划将继续放在跨学院生理学研究生计划中，该计划在跨学科研究生教育方面已有35年的历史。该培训计划的教职员工致力于通过招聘少数族裔来增强多样性，并促进研究中的道德规范。该培训计划寻求每年8名博士前实习生的支持，他们的熟练程度将通过严格的课程、结构化的研究经验和专注的指导来培养，以整合在多个层面上收集的信息。专门为这项计划开发了一门核心课程，“压力的生理适应”，并继续作为这一培训计划目标的早期介绍。两个校区都提供了丰富的学术环境，拥有强大的研究支持和机构承诺。宾夕法尼亚州立大学将继续提供四项完整的助学金，作为对这项培训的匹配。通过该计划完成培训的学生不仅将拥有从分子到整个生物体的全面实验室技术知识，而且他们还将有能力理解和综合通过研究检查对压力的生理适应而产生的复杂信息。

DESCRIPTION: (provided by applicant) The predoctoral training program entitled "Research Training in Physiological Adaptations to Stress" during its first funding period, has attracted excellent students and the five graduates of the program have obtained first rate postdoctoral positions or positions in industry. Sixty percent of the NIH funded slots are currently filled with minority students. Based on this success, we seek continued support of the program for another five years. Physiological adaptations to stress encompass a wide range of responses from alterations of molecular structure affecting cellular metabolism to organismal remodeling. Adaptations may be positive, such as those brought about by increased participation in regular physical activity, or they may have pathological sequelae such as hypermetabolic responses to trauma. Our predoctoral training program takes advantage of the existing, internationally recognized strengths of faculty located at the College of Medicine at the Hershey Campus and within several departments at the University Park campus of The Pennsylvania State University. The goal of the ongoing training program is to develop scientists with an ability to generate, integrate, and apply knowledge gathered by multiple approaches to the study of stress physiology. The training program will continue to be housed in the Intercollege Graduate Program in Physiology, which has a thirty-five year history of interdisciplinary graduate student education. Faculty members of the training program are committed to enhancing diversity through minority recruitment and to promoting ethics in research. The training program seeks support for 8 predoctoral trainees per year whose proficiency to integrate information gathered at many levels of inquiry will be developed by a rigorous curriculum, structured research experiences and dedicated mentorship. A core course has been developed specifically for this program, "Physiological Adaptations to Stress and continues to serve as an early introduction to the goals of this training program. A rich academic environment is provided at both campuses with strong research support and institutional commitment. The Pennsylvania State University will continue to provide four full assistantships as a match for this training grant. Students who complete their training through this program will not only have a thorough knowledge of laboratory techniques ranging from molecular to whole organism, but they will also have the capacity to understand and synthesize complex information resulting from research examining the physiological adaptations to stress.