Research Training in Physiological Adaptations to Stress

描述（由申请人提供）：这项名为“压力生理适应研究培训”的培训计划的主要目标是为新一代未来科学家提供全面的研究培训和教育经验，强调理解触发和介导生物体压力适应的生理机制的转化方法。强调个性化医疗作为一种模式的新兴领域，为学生创造性地思考健康和疾病中的压力适应机制提供了独特的机会，并帮助他们成为生物医学研究的创新者，并对整个转化科学有着广泛的认识。此外，我们提出了一个跨学科的课程，更好地为学生准备各种职业道路与21世纪世纪生物医学劳动力，包括一些监管和团队科学的理解。该培训计划利用现有教师的专业知识在七个单独的翻译研究集群，团结在th跨学院研究生课程在生理学在宾夕法尼亚州立大学的大学公园和好时校区的逻辑教师合作伙伴。沿着生理应激连续体的一般重点领域分别包括心血管、环境、免疫、代谢、神经内分泌、营养和生殖，采用体外和体内生理系统和尖端技术方法。该培训计划要求在第一年支持两名博士前学生，并建议在前三年增加到每年支持六名学生。由培训计划附属单位和宾夕法尼亚州立大学研究副总裁办公室承诺的额外9个学生年的支持将确保当该计划在第3年成熟时，每年为8名学生提供资金。专门为培训方案设计了一门题为“对压力的生理适应”的基础课程，这门课程将作为方案目标的早期介绍， 强调多层次的科学探究（从细胞到人类）。定义一个新的概念框架的假设驱动的研究，告知压力适应和创新的生物标志物的机制强调，在一个丰富的学术环境与专门的指导，强大的研究支持和机构的承诺。

DESCRIPTION (provided by applicant): The primary goal of this training program entitled "Research Training in Physiological Adaptations to Stress" is to provide a new generation of future scientists with comprehensive research training and educational experiences that emphasize a translational approach to understanding the physiological mechanisms which trigger and mediate organismal stress adaptation. An emphasis on the emerging field of personalized medicine as a model offers unique opportunities for students to think creatively about mechanisms of stress adaptation in health and disease, and to help them be innovators in biomedical research with a broad appreciation of translational science as a whole. Additionally, we propose an inter-disciplinary curriculum which better prepares students for varied career paths associated with the 21st century biomedical workforce, including some understanding of regulatory and team science. The training program takes advantage of existing faculty expertise within seven individual translational research clusters, uniting logical faculty partners within th Intercollege Graduate Program in Physiology at Penn State's University Park and Hershey campuses. General areas of emphasis along the physiological stress continuum include cardiovascular, environmental, immunological, metabolic, neuroendocrine, nutritional, and reproductive, respectively, employing in vitro and in vivo physiological systems and cutting edge technological approaches. The training program requests support for two predoctoral students in year 1 and proposes to grow over the first three years to supporting six students annually with grant funds. An additional nine student-years of support committed by units affiliated with the training program and the Office of the Penn State Vice President for Research will ensure funding for a total cohort of eight students per year when the program reaches maturity in Year 3. A foundational course entitled "Physiological Adaptations to Stress" has been designed specifically for the training program, and will serve as an early introduction to program goals and emphasizes multiple levels of scientific inquiry (cells to human). Defining a new conceptual framework for hypothesis-driven research to inform mechanisms of stress adaptation and innovative biomarkers is emphasized, within a rich academic environment with dedicated mentoring, strong research support and institutional commitment.