Research Training in Physiological Adaptations to Stress

项目摘要 这项名为“压力生理适应研究培训”的培训计划的主要目标是 为新一代的未来科学家提供全面的研究培训和教育 经验，强调翻译的方法来理解生理机制， 触发和调节生物应激适应。利用一个新的技术，提供企业家精神增值培训， 靴子训练营的方法，并通过宾夕法尼亚州立大学的MBA课程在团队动力学教学培训也是 重点介绍目前，研究生在监管科学领域很少接受正式培训 和团队动力，因此，我们还提出了一个跨学科的课程，其中包括培训， 新兴的学术和非学术职业准备。了解业务、法律的和 形成生物医学科学途径中关键里程碑的监管问题，以及在 多元化的团队将使我们的学员成为创新的领导者。在这里，严谨的研究设计和核心 还强调有效沟通所需的能力。总的来说，学生们 定位于与21世纪世纪生物医学劳动力相关的新兴职业道路。培训计划 利用现有的教师生物医学专业知识在九个参与计划谁积累了 学生培训的令人印象深刻的记录，同时保持卓越的研究（年度直接成本总额 约8，439，420美元，平均每个学院约351，643美元）。我们建议每年选择6名学生， 两年（共有18名学员）。额外的机构配套资金将用于培训另外8名 学生对我们的培训计划的机构承诺是杰出的。一门基础课程， “对压力的生理适应”也是专门为培训计划设计的， 作为一个顶点的经验，强调使用多层次的科学探究（细胞到人类）的计划目标。 为假设驱动的研究定义一个新的概念框架，以告知压力适应机制 在一个丰富的学术环境中，有专门的指导，强大的研究支持和机构 承诺已提出。我们预计学员将继续参加项目活动的结论 作为T32的成员。

PROJECT SUMMARY The primary goal of this training program entitled “Research Training in Physiological Adaptations to Stress” is to provide a new generation of future scientists with comprehensive research training and educational experiences that emphasize a translational approach to understanding the physiological mechanisms which trigger and mediate organismal stress adaptation. Value added training in business entrepreneurship using a boot camp approach, and didactic training in team dynamics through the Penn State MBA program is also emphasized. Graduate students presently encounter little formal training in the domains of regulatory science and team dynamics, and we therefore also propose an inter-disciplinary curriculum which includes training for emerging academic and nonacademic career preparation. An understanding of the business, legal and regulatory issues which shape key milestones in the biomedical science pathway, and the ability to work in diverse teams will allow our trainees to be leaders of innovation. Here, rigorous research design and core competencies necessary for effective communication are also emphasized. Collectively, students will be well positioned for emerging career paths associated with the 21st century biomedical workforce. The training program takes advantage of existing faculty biomedical expertise within nine participating programs who have amassed an impressive record of student training while maintaining research excellence (total annual direct cost of ~$8,439,420 and an average of ~$351,643 per faculty). We propose selection of 6 students per year for a period of two years (total of 18 trainees). Additional institutional matching funds will allow for the training of 8 additional students. The institutional commitment to our training program is outstanding. A foundational course entitled “Physiological Adaptations to Stress” has also been designed specifically for the training program, and will serve as a capstone experience to emphasize program goals using multiple levels of scientific inquiry (cells to human). Defining a new conceptual framework for hypothesis-driven research to inform mechanisms of stress adaptation within a rich academic environment with dedicated mentoring, strong research support and institutional commitment is proposed. We envision trainees will continue to participate in program activities at the conclusion of their tenure as a T32 Fellow.