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Research Training in Physiological Adaptations to Stress

压力生理适应研究培训

基本信息

批准号：
10650350
负责人：
MARGHERITA T CANTORNA
金额：
$ 20.28万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10650350
关键词：
Physiological Adaptation Research Training Stress

项目摘要

PROJECT SUMMARY The primary goal of this training program entitled “Research Training in Physiological Adaptations to Stress” is to provide a new generation of future scientists with comprehensive research training and educational experiences that emphasize a translational approach to understanding the physiological mechanisms which trigger and mediate organismal stress adaptation. Value added training in business entrepreneurship using a boot camp approach, and didactic training in team dynamics through the Penn State MBA program is also emphasized. Graduate students presently encounter little formal training in the domains of regulatory science and team dynamics, and we therefore also propose an inter-disciplinary curriculum which includes training for emerging academic and nonacademic career preparation. An understanding of the business, legal and regulatory issues which shape key milestones in the biomedical science pathway, and the ability to work in diverse teams will allow our trainees to be leaders of innovation. Here, rigorous research design and core competencies necessary for effective communication are also emphasized. Collectively, students will be well positioned for emerging career paths associated with the 21st century biomedical workforce. The training program takes advantage of existing faculty biomedical expertise within nine participating programs who have amassed an impressive record of student training while maintaining research excellence (total annual direct cost of ~$8,439,420 and an average of ~$351,643 per faculty). We propose selection of 6 students per year for a period of two years (total of 18 trainees). Additional institutional matching funds will allow for the training of 8 additional students. The institutional commitment to our training program is outstanding. A foundational course entitled “Physiological Adaptations to Stress” has also been designed specifically for the training program, and will serve as a capstone experience to emphasize program goals using multiple levels of scientific inquiry (cells to human). Defining a new conceptual framework for hypothesis-driven research to inform mechanisms of stress adaptation within a rich academic environment with dedicated mentoring, strong research support and institutional commitment is proposed. We envision trainees will continue to participate in program activities at the conclusion of their tenure as a T32 Fellow.

项目摘要这项名为“压力生理适应研究培训”的培训计划的主要目标是为新一代的未来科学家提供全面的研究培训和教育经验，强调翻译的方法来理解生理机制，触发和调节生物应激适应。利用一个新的技术，提供企业家精神增值培训，靴子训练营的方法，并通过宾夕法尼亚州立大学的MBA课程在团队动力学教学培训也是重点介绍目前，研究生在监管科学领域很少接受正式培训和团队动力，因此，我们还提出了一个跨学科的课程，其中包括培训，新兴的学术和非学术职业准备。了解业务、法律的和形成生物医学科学途径中关键里程碑的监管问题，以及在多元化的团队将使我们的学员成为创新的领导者。在这里，严谨的研究设计和核心还强调有效沟通所需的能力。总的来说，学生们定位于与21世纪世纪生物医学劳动力相关的新兴职业道路。培训计划利用现有的教师生物医学专业知识在九个参与计划谁积累了学生培训的令人印象深刻的记录，同时保持卓越的研究（年度直接成本总额约8，439，420美元，平均每个学院约351，643美元）。我们建议每年选择6名学生，两年（共18名学员）。额外的机构配套资金将用于培训另外8名学生对我们的培训计划的机构承诺是杰出的。一门基础课程， “对压力的生理适应”也是专门为培训计划设计的，作为一个顶点的经验，强调使用多层次的科学探究（细胞到人类）的计划目标。为假设驱动的研究定义一个新的概念框架，以告知压力适应机制在一个丰富的学术环境中，有专门的指导，强大的研究支持和机构承诺已提出。我们预计学员将继续参加项目活动的结论作为T32的成员。

项目成果

期刊论文数量（53）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Physical Activity and Breast Cancer Prevention: Possible Role of Immune Mediators.

DOI：
10.3389/fnut.2020.557997
发表时间：
2020
期刊：
Frontiers in nutrition
影响因子：
5
作者：
Xu Y;Rogers CJ
通讯作者：
Rogers CJ

Impact of physical activity and energy restriction on immune regulation of cancer.

体育活动和能量限制对癌症免疫调节的影响。

DOI：
10.21037/tcr.2020.03.38
发表时间：
2020-09
期刊：
Translational cancer research
影响因子：
0.9
作者：
Xu Y;Rogers CJ
通讯作者：
Rogers CJ

Western and heart healthy dietary patterns differentially affect the expression of genes associated with lipid metabolism, interferon signaling and inflammation in the jejunum of Ossabaw pigs.

DOI：
10.1016/j.jnutbio.2020.108577
发表时间：
2021-04
期刊：
The Journal of nutritional biochemistry
影响因子：
0
作者：
Ye S;Matthan NR;Lamon-Fava S;Aguilar GS;Turner JR;Walker ME;Chai Z;Lakshman S;Urban JF Jr;Lichtenstein AH
通讯作者：
Lichtenstein AH

Inhaled corticosteroids as treatment for adolescent asthma: effects on adult anxiety-related outcomes in a murine model.