Research Training in Physiological Adaptations to Stress

压力生理适应研究培训

• 批准号: 8742892
• 负责人: LEONARD S JEFFERSON
• 金额: $ 8.39万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8742892
• 关键词: Physiological Adaptation; Research Training; Stress

DESCRIPTION (provided by applicant): The primary goal of this training program entitled "Research Training in Physiological Adaptations to Stress" is to provide a new generation of future scientists with comprehensive research training and educational experiences that emphasize a translational approach to understanding the physiological mechanisms which trigger and mediate organismal stress adaptation. An emphasis on the emerging field of personalized medicine as a model offers unique opportunities for students to think creatively about mechanisms of stress adaptation in health and disease, and to help them be innovators in biomedical research with a broad appreciation of translational science as a whole. Additionally, we propose an inter-disciplinary curriculum which better prepares students for varied career paths associated with the 21st century biomedical workforce, including some understanding of regulatory and team science. The training program takes advantage of existing faculty expertise within seven individual translational research clusters, uniting logical faculty partners within th Intercollege Graduate Program in Physiology at Penn State's University Park and Hershey campuses. General areas of emphasis along the physiological stress continuum include cardiovascular, environmental, immunological, metabolic, neuroendocrine, nutritional, and reproductive, respectively, employing in vitro and in vivo physiological systems and cutting edge technological approaches. The training program requests support for two predoctoral students in year 1 and proposes to grow over the first three years to supporting six students annually with grant funds. An additional nine student-years of support committed by units affiliated with the training program and the Office of the Penn State Vice President for Research will ensure funding for a total cohort of eight students per year when the program reaches maturity in Year 3. A foundational course entitled "Physiological Adaptations to Stress" has been designed specifically for the training program, and will serve as an early introduction to program goals and emphasizes multiple levels of scientific inquiry (cells to human). Defining a new conceptual framework for hypothesis-driven research to inform mechanisms of stress adaptation and innovative biomarkers is emphasized, within a rich academic environment with dedicated mentoring, strong research support and institutional commitment.

描述(由申请者提供)：这项名为“生理适应压力的研究培训”的培训计划的主要目标是为新一代未来科学家提供全面的研究培训和教育经验，强调以翻译的方法理解触发和调节生物压力适应的生理机制。强调以个性化医学这一新兴领域为榜样，为学生提供了创造性地思考健康和疾病中压力适应机制的独特机会，并帮助他们成为生物医学研究的创新者，对整个翻译科学具有广泛的鉴赏力。此外，我们提出了一个跨学科的课程，更好地为学生准备与21世纪生物医学劳动力相关的各种职业道路，包括对监管和团队科学的一些理解。该培训计划利用七个单独的翻译研究集群中现有的教师专业知识，将宾夕法尼亚州立大学园区和好时校区的大学间生理学研究生计划中的逻辑教师合作伙伴联合起来。沿着生理应激连续体的一般重点领域分别包括心血管、环境、免疫、代谢、神经内分泌、营养和生殖，采用体外和体内生理系统和尖端技术方法。该培训计划要求在第一年支持两名博士前学生，并提议在前三年增加到每年用助学金支持六名学生。附属于培训计划的单位和宾夕法尼亚州立大学副总统办公室承诺的额外9个学生年的支持将确保当计划在第三年成熟时，每年为总共8名学生提供资金。专门为培训计划设计了一门名为“对压力的生理适应”的基础课程，作为对计划目标和 强调多层次的科学研究(从细胞到人)。强调在一个有专门指导、强有力的研究支持和机构承诺的丰富的学术环境中，为假设驱动的研究定义一个新的概念框架，以告知压力适应和创新的生物标志物的机制。