Research Training in Physiological Adaptations to Stress

项目总结 这项名为“生理适应压力的研究训练”的训练计划的主要目标是 为新一代未来科学家提供全面的研究培训和教育 强调翻译方法来理解生理机制的经验 触发和调节机体的压力适应。企业创业增值培训使用 新兵训练营的方法，以及通过宾夕法尼亚州立大学MBA项目进行的团队动力学教学培训也是 强调。目前，研究生在监管科学领域几乎没有受到过正规培训。 和团队动力，因此我们还提出了一个跨学科的课程，其中包括 新兴的学术和非学术职业准备。了解业务、法律和 形成生物医学科学道路上关键里程碑的监管问题，以及在 多样化的团队将使我们的学员成为创新的领导者。在这里，严谨的研究设计和核心 还强调了有效沟通所必需的能力。集体来说，学生们会很好的 定位于与21世纪生物医学劳动力相关的新兴职业道路。培训计划 利用九个参与计划中现有的教师生物医学专业知识，这些计划积累了 令人印象深刻的学生培训记录，同时保持卓越的研究成果(年度直接成本总额 约8,439,420美元，每名教职员工平均约351,643美元)。我们建议每年选拔6名学生，为期一段时间 为期两年(共18名实习生)。额外的机构配对资金将用于培训另外8名 学生们。机构对我们培训计划的承诺是杰出的。这是一门名为 “对压力的生理适应”也是专门为培训计划设计的，并将发挥作用 作为强调项目目标的最高体验，使用多层次的科学研究(从细胞到人)。 为假设驱动的研究定义一个新的概念框架，为压力适应机制提供信息 在丰富的学术环境中，拥有专注的指导、强大的研究支持和机构 建议作出承诺。我们预计学员将在结束时继续参加计划活动 他们作为T32研究员的任期。

PROJECT SUMMARY The primary goal of this training program entitled “Research Training in Physiological Adaptations to Stress” is to provide a new generation of future scientists with comprehensive research training and educational experiences that emphasize a translational approach to understanding the physiological mechanisms which trigger and mediate organismal stress adaptation. Value added training in business entrepreneurship using a boot camp approach, and didactic training in team dynamics through the Penn State MBA program is also emphasized. Graduate students presently encounter little formal training in the domains of regulatory science and team dynamics, and we therefore also propose an inter-disciplinary curriculum which includes training for emerging academic and nonacademic career preparation. An understanding of the business, legal and regulatory issues which shape key milestones in the biomedical science pathway, and the ability to work in diverse teams will allow our trainees to be leaders of innovation. Here, rigorous research design and core competencies necessary for effective communication are also emphasized. Collectively, students will be well positioned for emerging career paths associated with the 21st century biomedical workforce. The training program takes advantage of existing faculty biomedical expertise within nine participating programs who have amassed an impressive record of student training while maintaining research excellence (total annual direct cost of ~$8,439,420 and an average of ~$351,643 per faculty). We propose selection of 6 students per year for a period of two years (total of 18 trainees). Additional institutional matching funds will allow for the training of 8 additional students. The institutional commitment to our training program is outstanding. A foundational course entitled “Physiological Adaptations to Stress” has also been designed specifically for the training program, and will serve as a capstone experience to emphasize program goals using multiple levels of scientific inquiry (cells to human). Defining a new conceptual framework for hypothesis-driven research to inform mechanisms of stress adaptation within a rich academic environment with dedicated mentoring, strong research support and institutional commitment is proposed. We envision trainees will continue to participate in program activities at the conclusion of their tenure as a T32 Fellow.