TESTOSTERONE EFFECTS ON MUSCLE IN BURN INJURY

烧伤和伴随的激素环境导致骨骼肌剧烈的痉挛。 高皮质醇血症和睾酮产生不足的组合导致氨基酸从骨骼肌的净流出，进而导致肌肉蛋白质的损失。 骨骼肌的这种损失阻碍了患者的康复，并增加了恢复工作所需的时间。 这是该建议的目的是调查的一般假设，在烧伤患者的睾酮正常化将改善骨骼肌的高钙通过增加净蛋白质合成和减少细胞内氨基酸的净流出。 该建议的另一个目标是研究睾酮的作用将通过增加内向氨基酸转运而放大的假设。 促进内向氨基酸转运的干预措施，如氨基酸输注和抗阻运动，将与睾酮给药一起研究。 该提案将评估恢复的可行性。出院后，睾酮正常化将通过确定其对肌肉蛋白质合成和分解、瘦体重、肌肉质量和肌肉力量的影响来解决。

Burn injury and the accompanying hormonal milieu result in a dramatic catabolism of skeletal muscle. The combination of hypercortisolemia and insufficient testosterone production contribute to a net efflux of amino acids from skeletal muscle, and in turn, a loss of muscle protein. This loss of skeletal muscle impedes the patients rehabilitation and increases the time required to return to work. It is the goal of this proposal to investigate the general hypothesis that testosterone normalization in the burned patient will ameliorate the hypercatabolism of skeletal muscle by increasing net protein synthesis and decreasing the net efflux of intracellular amino acids. A further goal of this proposal is to investigate the hypothesis that the effects of testosterone will be amplified by increased inward amino acid transport. Interventions which promote inward amino acid transport, such as amino acid infusion and resistance exercise, will be investigated in conjunction with testosterone administration. This proposal will evaluate the feasibility of rehabilitation. Upon discharge, testosterone normalization will be addressed by determining its effects on muscle protein synthesis and breakdown, lean body mass, muscle mass, and muscular strength.