CORE--BIOENGINEERING AND BASIC SCIENCE

描述：(申请人提供)工程和基础课程的目标 科学核心是推动老年学和老年医学研究 临床医生、临床研究人员、基础科学家和工程师以及 通过为该学院的教师和学员提供尖端技术 老龄问题分组。这一核心将促进新发现的发展 在诊断和治疗方面的改进将增强独立性 关于老年人的问题。具体地说，这个核心被设计成使工程和 一般可获得的细胞和分子生物学研究机会 老龄问题司成员提供下列服务：1)a) 步态评估服务为以病人为中心的步态评估提供设备 步态实验室外的环境。2)非线性分析 服务部门在分析方法的应用方面提供专家帮助 从统计物理学和“混沌”理论衍生到(病理生理学)的研究 时间序列和空间测量。3)生物数据 采购处为以下产品租用传感器、放大器和录音机 监测生理信号(例如，心电、血压) 衰老和老年性疾病研究的实验。4)一种生物 信号处理服务数字化、显示和分析生物 信号。5)图像采集服务提供对研究等级的访问 荧光视频显微镜和串列扫描共聚焦显微镜。6)一个 图像处理和口译服务执行数字图像处理 图像的图像。7)转基因动物设计服务提供技术援助 关于制备适当的DNA构建物和/或创建 特定的基因突变。8)基因组扫描服务协助调查人员 随着这些基因组序列和DNA标记板的鉴定 可能与晚年流行的疾病有关，如心脏 疾病、癌症和神经退行性疾病。9)基因表达谱 服务提供对高吞吐量技术的访问，以实现 衰老及不同年龄相关的基因表达谱特征 疾病状态。10)未来设计服务的“原地养老”之家 帮助开发一个特别设计成 最大限度地提高老年人的独立性，扩大他们的生活能力 在社区中取得了成功。

Description: (provided by the applicant) The goal of the Engineering and Basic Science Core is to promote gerontologic and geriatric research by bringing together clinicians, clinical researchers, basic scientists and engineers and by offering cutting-edge technology to the faculty and trainees of the Division on Aging. This core will foster the development of new discoveries and improvements in diagnosis and therapy that will enhance the independence of older persons. Specifically, this core is designed to make engineering and cell and molecular biology research opportunities generally accessible to members of the Division on Aging by providing the following services: 1) A Gait Assessment Service loans equipment for the assessment of gait in patient-oriented settings outside of the gait laboratory. 2) A Nonlinear Analysis Service provides expert assistance in the application of analysis methods derived from statistical physics and "chaos" theory to the study of (patho-physiologic time series and spatial measurements. 3) A Biological Data Acquisition Service loans transducers, amplifiers, and recorders for the monitoring of physiological signals (e.g., ECG, blood pressure) during experiments of the study of aging and age-related disease. 4) A Biological Signal Processing Service digitizes, displays, and analyzes biological signals. 5) An Image Acquisition Service provides access to a research grade fluorescence video microscope and tandem scanning confocal microscopes. 6) An Image Processing and Interpretation Service performs digital image processing of images. 7) A Transgenic Animal Design Service provides technical assistance regarding preparation of the appropriate DNA construct and/or creation of specific gene mutations. 8) A Genome Scanning Service assists the investigator with the identification of those genomic sequences and DNA marker panels that may be associated with the prevalent diseases of late life, such as heart disease, cancer, and neurodegenerative diseases. 9) A Gene Expression Profile Service provides access to high throughput technology for the performance of gene expression profile characterization of aging and various age-associated disease states. 10) An "Aging In Place" Home of the Future Design Service assists in the development of a living-space that is especially designed to maximize the independence of older persons and extend their ability to live successfully in the community.