HUMAN IMMUNE CELL MATURATION DURING ONTOGENY AND INFECTI

人类免疫细胞在个体发育和感染过程中的成熟这个项目代表了加州大学旧金山分校和斯坦福大学的五名研究人员之间的一项新的、有前途的合作，他们都致力于人类免疫学方面的互补方面的工作。在各个单元中解决的五个问题研究了在个体发育和感染期间影响人类免疫细胞成熟的调节机制。每个Site描述了与项目中至少一名其他调查人员的合作，并反映了参与调查人员的共同兴趣和专业知识。我们所有的实验室都致力于研究人类的免疫反应。这一承诺源于对人类疾病的兴趣，以及这样一个事实，即一些研究系统在人类中使用的系统与流行的小鼠模型系统明显不同。这些拟议的项目共同定义了与小鼠和非人类灵长类系统相比的人类免疫反应的独特方面，分析了信号和膜交通在调节人类淋巴发育中的作用，并研究了人类传染病对淋巴成熟和功能的影响。

HUMAN IMMUNE CELL MATURATION DURING ONTOGENY AND INFECTION This program represents a new and promising collaboration between five investigators at the University of California, San Francisco and Stanford University, all of whom work on complementary aspects on human immunology. The five problems addressed in the individual units investigate regulatory mechanisms influencing human immune cell maturation during ontogeny and infection. Each sit describes a collaboration with at least one other investigator in the program and reflects the shared interests and expertise of the investigators involved. All of our laboratories are committed to studying the human immune response. This commitment arises broth from an interest in human disease and the fact that several of use study systems that are markedly different in humans than in the prevailing mouse model systems. Together the proposed projects define unique aspects of the human immune response in comparison to murine and non-human primate systems, analyze the role of signaling and membrane traffic in regulation of human lymphoid development and study the effects of infectious diseases in humans on lymphoid maturation and function.