UTMB MASS SPECTROMETRY/PROTEOMICS FACILITY

描述：(申请人的描述)这项建议旨在开发一种 质谱学/蛋白质组学设施为UTMB调查人员提供 增强了识别和表征蛋白质的分析能力 与癌症和肿瘤学的蛋白质表达变化有关。那里 UTMB大约有37笔由NCI支持的赠款，总计 目前的直接成本资金约为1320万美元。其中七个 描述NCI支持的项目是为了强调 在UTMB开发质谱学和蛋白质组学核心设施。这 该设施将在UTMB蛋白质化学实验室内运行， 建立了集中式核心服务，具有强大的提供 UTMB研究界提供与蛋白质有关的分析服务， 多肽和氨基酸。这笔赠款将允许UTMB癌症研究人员 利用以下领域的新发展和新能力 蛋白质/多肽的质谱学表征，因此相当可观 加强NCI支持的校园研究。奖助金最初将是 用于购买蛋白质组学设备，并在持续的基础上提供 运营所需的人员、用品和部分服务合同 设施。还要求提供支持，以激励新的和年轻的调查人员 通过提供尖端技术进行癌症研究 疾病相关蛋白的表达。除了所描述的七个NCI- 资助的项目，UTMB的其他NIH研究调查人员预计也将 从这笔赠款中受益。一般而言，来自这笔赠款的资金将 大幅降低分析费用，从而鼓励 癌症研究人员利用这一资源。UTMB承诺 发展这一设施的重要贡献是 空间、设备和工资支持。设立了一个咨询委员会，以 确保赠款的目标得以实现，并确保设施将 继续运作到未来几年。

DESCRIPTION: (Applicant's Description) This proposal is aimed at developing a mass spectrometry/proteomics facility to provide UTMB investigators with enhanced analytical capabilities to identify and characterize proteins associated with cancer and oncological changes in protein expression. There are approximately 37 NCI-supported grants at UTMB with a combined total current direct cost funding of about $13.2 million dollars. Seven of these NCI-supported projects are described to underscore the critical importance of developing a mass spectrometry and proteomics core facility at UTMB. This facility will operate within the UTMB Protein Chemistry Laboratory, an established centralized core service that has a strong history of providing the UTMB research community with analytical services relating to proteins, peptides, and amino acids. This grant will allow UTMB cancer researchers to take advantage of new developments and capabilities in the area of protein/peptide characterization by mass spectrometry, and so considerably enhance NCI-supported research on the campus. Grant funds will be initially used to purchase proteomics equipment, and on an ongoing basis, to provide the necessary personnel, supplies, and partial service contracts to operate the facility. Support is also requested to stimulate new and young investigator cancer research by providing cutting-edge technology for the identification of disease-associated protein expression. In addition to the seven described NCI- funded projects, other NIH research investigators at UTMB are also expected to benefit from this grant. In general, funding from this grant will significantly reduce the charge-back fees for analyses, and so encourage cancer investigators to utilize this resource. UTMB's commitment to developing this facility is underscored by a considerable contribution of space, equipment, and salary support. An advisory committee is in place to insure that the goals of the grant are achieved and that the facility will continue to operate into future years.