Cumulative Risks and Asthma Morbidity in Urban Children

产品说明：（由申请人提供）哮喘是一种儿童慢性疾病，在美国低收入、城市和少数民族背景的儿童中发病率过高（USDHHS，2000）。在这一人口特征中，儿童哮喘发病率和死亡率的稳步上升已被确定为一个重要的国家健康问题。美国国立卫生研究院的一个主要研究重点是了解如何减少少数民族，低收入儿童和他们的健康，白色同行之间的健康差距。本研究将在非裔美国人、西班牙裔和非西班牙裔白色儿童（N= 150，每个种族组50个家庭）中检查与城市贫困相关的多种风险的累积影响与哮喘发病率之间的关系。具体而言，将采用累积风险指数（CRI）的开发和验证来调查城市儿童哮喘发病率是否可以通过风险模型更充分地预测，该风险模型包括可能作为城市家庭风险（文化，背景，哮喘特异性）的多个因素。城市和低收入的7-11岁哮喘儿童及其主要照顾者将参加基于访谈的评估。目前的研究将被整合到NIH资助的布朗医学院哮喘差异中心（U 01-HIO 72438 -01;首席研究员Gregory Fritz）。这项研究的结果将使未来的研究测试主持人，可能会提高城市儿童哮喘相关的功能。

DESCRIPTION: (provided by applicant) Asthma is a childhood chronic illness that is over-represented in children from low income, urban, and ethnic minority backgrounds in the U.S. (USDHHS, 2000). The steady increase in asthma morbidity and mortality rates among children within this demographic profile has been identified as a significant national health concern. A major research priority for NIH is to understand how to decrease the health disparities between ethnic minority, low-income children and their healthier, white counterparts. The present study will examine the relationship between the cumulative impact of multiple risks associated with urban poverty and asthma morbidity in African-American, Hispanic, and non- Hispanic, white children (N= 150, 50 families in each ethnic group). Specifically, the development and validation of a Cumulative Risk Index (CRI) will be employed to investigate whether asthma morbidity in urban children is more adequately predicted by risk models that include multiple dimensions of factors that may function as risks (cultural, contextual, asthma-specific) for urban families. Urban and low-income, 7-11 year old children with asthma and their primary caregivers will participate in interview-based assessments. The current study will be integrated into an NIH funded Center for Asthma Disparities (U01-HIO72438-01; Principal Investigator Gregory Fritz) at Brown Medical School. Results from this study will enable future studies testing moderators that may enhance asthma-related functioning in urban children.