Molecular Imaging: Training for Oncology

描述(申请人提供)：该项目的目标是培养新一代的研究人员，使其能够熟练掌握生物学和“分子成像”技术。“分子成像”一词已被应用于结合两个互补科学发展的成像技术，即1)成像技术的改进导致实验室和临床应用的更多用途和更高分辨率的成像方式；2)对癌症生物学理解的进步，这被用来为肿瘤发生的关键分子和相关的生化事件制造成像探针。随着知识的增长，如果这些进展要迅速转化为癌症发现，就需要进行跨学科培训。在纪念斯隆-凯特琳癌症中心，分子成像能力和资源得到了国家癌症研究所资助的倡议的快速增长，这些倡议包括活体细胞和分子成像中心的P50计划、小动物成像资源计划以及多肿瘤学指导的PO1‘S、孢子和RO1’S，强调癌症的多模式生物成像。这一“团队科学”经验表明，需要从两个不同的角度进行培训：临床研究人员需要更多的分子生物学和实验室成像方法的培训；基础研究人员需要专业成像方法的培训，以及更专注和相关的临床肿瘤学观点。此R25T计划旨在满足这些多样化的培训需求。该计划将通过一个内部咨询委员会进行管理，该委员会由具有肿瘤学研究生医学教育经验的临床和基础教职员工组成。导师将从NCI资助的一群杰出的癌症研究人员中挑选出来。将招聘基础和临床实习生，重点是少数群体的平等机会。专业课程将包括相关的分子生物学、研究方法论、先进成像方法的指导，以及基础、转换和临床的个性化研究计划。

DESCRIPTION (provided by applicant): The goal of this program is to train a new generation of researchers, to become facile with both the biology and the technology of "molecular imaging". The term "molecular imaging" has been applied to imaging techniques that combine benefits from 2 complementary scientific developments, namely, 1) the improving technology of imaging leading to ever more versatile and high resolution imaging modalities for both laboratory and clinical applications; 2) advances in understanding of cancer biology which are exploited to create imaging probes for the key molecules and related biochemical events that are fundamental to neoplasia. As knowledge increases, interdisciplinary training will be needed, if these advances are going to be quickly translated into cancer discovery. At Memorial Sloan-Kettering Cancer Center (MSKCC), there has been rapid growth in molecular imaging capabilities and resources fueled by NCI funded initiatives including the P50 In Vivo Cellular and Molecular Imaging Center (ICMIC), the small animal imaging resource program (SAIRP), and multiple oncology directed PO1 's, SPORES, and RO1's that stress the multimodality biologic imaging of cancer. This "team science" experience suggests that training is required from 2 distinct points of perspectives: clinical researchers need more molecular biology and training in laboratory imaging methods; basic researchers need training in specialized imaging methods, and a more focused and relevant clinical oncology perspective. This R25T program is designed to meet these diverse training needs. The program will be managed through an internal advisory committee consisting of clinical and basic faculty with experience in graduate medical education in oncology. Mentors will be drawn from a distinguished group of NCI supported cancer researchers. Both basic and clinical trainees will be recruited, with emphasis on equal opportunities for minorities. A specialized curriculum will include the relevant molecular biology, research methodology, instruction in advanced imaging methods, and an individualized research program of basic, translational and clinical.