EXPERIMENTAL GENETICS

癌症是一种遗传复杂、生物异质性的疾病。越来越清楚的是，实验室小鼠作为人类最好的基因定义的实验模型生物，为快速推进对癌症遗传基础的理解提供了一个重要的机会。因此，在小鼠遗传学、基因组学和生物学方面进行广泛的培训对于实现这一目标至关重要。本课程的总体目标是培养年轻科学家（博士前、博士后培训生、新研究者），并对已有的研究者进行再培训，使他们能够使用基因定义的实验室小鼠作为基因工具，提出有关基因功能的问题。完成本课程的学生将获得实验方法的工作和关键知识：(1)小鼠遗传学和基因组学，(2)哺乳动物发育，(3)人类疾病的小鼠模型，(4)基因研究的伦理观点。这些目标将通过为30名具有杰出研究潜力的学生提供为期两周的强化课程来实现。他们将与一群来自杰克逊实验室和其他机构的著名老鼠遗传学家和生物学家进行互动。学生入学人数刻意保持在较小的规模，以达到期望的师生互动的高水平。该课程在Highseas的一个静修场所举行，Jackson实验室的海滨会议中心是课程演示和学生和教师住宿的场所。讲座，研讨会和示范在上午，下午和晚上举行，总共87个小时的正式教学。杰克逊实验室是nci指定的基础研究癌症中心，在提供高级课程和科学会议方面有着悠久的历史，包括与约翰霍普金斯大学共同组织的著名的“短期课程”，并在这里连续举办了37年。本申请所述的实验室小鼠实验遗传学课程自1992年以来每年举办一次。首席研究员和组织委员会在组织和讲授Jackson实验室主办的课程和会议方面有丰富的经验。

Cancer is a genetically complex and biologically heterogeneous group of disorders. It has become increasingly clear that the - laboratory mouse, the best genetically-defined experimental model organism for humans, presents a major opportunity for rapid advancement in understanding the genetic basis of cancer. Therefore, a broad-based training in mouse genetics, genomics and biology is critical to meet this end. The overall goal for our course is to train young scientists (predoctoral, postdoctoral trainees, new investigators) and to retrain established investigators in the use of genetically-defined laboratory mice as genetic tools for asking questions about gene function. Students completing the course will acquire working and critical knowledge of experimental approaches to: (1) Mouse genetics and genomics, (2) Mammalian development, (3) Mouse models for human diseases, (4) Ethical perspectives of genetic research. These Aims will be accomplished by offering an intensive 2-week course to 30 students chosen for their outstanding research potential. They will interact with a group of prominent mouse geneticists and biologists both from The Jackson Laboratory and other institutions. Student enrollment is kept deliberately small to achieve the desired high level of student-faculty interaction. The course is held in a retreat setting at Highseas, a Jackson Laboratory oceanfront conference center that is the site both for the course presentations and residential accommodations for the students and faculty. Lectures, workshops, and demonstrations are held mornings, afternoons, and evenings for a total of 87 hours of formal instruction. The Jackson Laboratory is an NCI-designated Basic Research Cancer Center and has a long history of presenting advanced courses and scientific meetings including the renowned "Short Course" co-organized with Johns Hopkins University and held here continuously for 37 years. The course on Experimental Genetics of the Laboratory Mouse described in this application has been held annually since 1992. The Principal Investigator and the Organizing Committee collectively have extensive experience in organizing and lecturing in Jackson Laboratory-sponsored and other courses and meetings.