Evolution of bacterial pathogenesis

关于从良性或轻度毒性种群中出现高毒性微生物病原体所涉及的具体进化步骤，人们知之甚少。A组链球菌是这个令人烦恼的问题的典型-存在大量细菌储存库，仅引起轻度感染，并且出现高度毒性菌株，引起显著疾病和死亡率。利用广泛的世卫组织参考A组链球菌分离株。该项目将定义产生最重要的入侵菌株M1 T1的进化事件。M1 T1菌株出现于20世纪80年代中期，此后在全球范围内传播，但导致这种出现的事件的进化顺序在很大程度上是未知的。

Little is known regarding the specific evolutionary steps involved in the emergence of highly virulent microbial pathogens from benign or mildly virulent populations. The group A streptococcus is exemplary of this vexing problem - a large population reservoir of bacteria exists causing only mild infections and a highly virulent strain emerges causing significant disease and mortality. Utilising an extensive WHO reference collection of group A streptococcus isolates. This project will define the evolutionary events that produced the most significant invasive strain designated M1T1. The M1T1 strain emerged in the mid-1980s, has since disseminated globally, yet the evolutionary sequence of events resulting in this emergence are largely unknown.