Symptom Based Transitions in Addiction in Male Twins

描述：（申请人提供） 请求提供3年支助，以进行过渡的二次分析 使用NIDA资助的哈佛药物研究（HDS）的数据， 其中8169名成员的越南时代双胞胎登记处（VETR）（一个大将军 在1970年代在军队服役的男性同性双胞胎的人口样本 越南时代）通过电话采访了一个结构化的精神病 诊断面试访谈中涵盖的是DSM-III-R寿命标准 对5类非法药物和2类合法药物的依赖和滥用，以及 其他精神疾病。是否有发病年龄和抵消年龄 这些数据中的每种药物类成瘾的具体症状使它们成为独特的 适用于我们现有的研究药物成瘾转变的方法 已成功用于酒精症状数据。双晶结构 数据允许研究遗传因素对发生的影响， 过渡到对特定药物成瘾。具体而言，我们将：1）探索 药物类特定成瘾的疾病分类学，并研究 分类中的遗传因素，使用潜在结构技术，如 潜在类别分析; 2）调查两者中成瘾的转变 流行病学和遗传学框架，使用a）更传统的方法 依赖于药物使用模式（例如，开始使用、经常使用和问题使用）， 以及B）基于人-年成瘾症状的新方法， 开发一种方法，用于合并症状偏移; 3）研究因素 （包括使用其他药物、精神并发症、社会 特征，家族史），可能促进，加速，或抑制 过渡;以及4）尽可能使用 其他数据来源，特别是越南时代研究（VES）的数据， 全国科摩罗调查（NCS），全国纵向酒精流行病学 调查（NLAES）和酗酒遗传学合作研究 （COGA），以测试结果的可复制性。我们期望我们 拟议的分析将有助于理解 对特定类型的毒品上瘾。最终，我们的研究可能表明 在特定的药物成瘾的过渡点， 进行预防性干预。

DESCRIPTION: (provided by applicant) Support is requested for 3 years to conduct secondary analyses of transitions in drug addiction, using data from the NIDA-funded Harvard Drug Study (HDS), in which 8169 members of the Vietnam Era Twin Registry (VETR) (a large general population sample of male same-sex twins who served in the military during the Vietnam era) were interviewed by telephone with a structured psychiatric diagnostic interview. Covered in the interview were DSM-III-R lifetime criteria for dependence and abuse on 5 illicit and 2 licit drug classes, as well as other psychiatric disorders. The availability of ages of onset and offset for each drug-class specific symptom of addiction in these data make them uniquely suitable for a method of studying transitions to drug addiction that we have already used successfully with alcohol symptom data. The twin structure of the data permits study of the effect of genetic factors on occurrence and transitions to addiction on specific drugs. Specifically we will: 1) explore the nosology of drug-class specific addictions and investigate the role of genetic factors in the classifications, using latent structure techniques like latent class analysis; 2) investigate transitions in addiction in both epidemiologic and genetic frameworks, using a) a more conventional approach that relies on drug use patterns (e.g. initiation, regular and problem use), as well as b) a novel approach based on person-years of addiction symptoms, developing a method for incorporating symptom offsets; 3) study factors (including use of other substances, psychiatric comorbidity, social characteristics, family history) that may promote, accelerate, or inhibit transitions; and 4) conduct, wherever possible, cross-study analyses using other sources of data, especially data from the Vietnam Era Study (VES), National Comorbidity Survey (NCS), National Longitudinal Alcohol Epidemiology Survey (NLAES), and the Collaborative Study on the Genetics of Alcoholism (COGA), in order to test the replicability of the findings. We expect our proposed analyses will contribute to an understanding of transitions in addiction to specific types of drugs. Ultimately, our research may suggest certain points in transitions in specific drug addictions that might be amenable to preventive interventions.