CONTRIBUTIONS OF MEG TO THE SURGICAL MGMT OF EPILEPSY

描述：（逐字来自申请人的摘要） 该项目旨在评估脑磁图（MEG）对 癫痫的外科治疗具体而言，我们提出以下建议：第一， 估计MEG的相对准确度，与表面和 侵入性电生理学，用于确定要切除的致痫区 局灶性癫痫患者中。第二，探讨 基于MEG数据结合来自 其他标准的非侵入性诊断程序和来自WADA的数据 在某些情况下，程序可能足够准确，以满足 侵入性电生理学此外，我们建议研究 对语言和记忆的不同半球参与的判断 从MEG数据中导出的结果与常规Wada程序中导出的结果一致。 最后，在回答上述主要问题时，我们还将 解决MEG是否影响侵入性计划的问题 电生理程序，我们将探索替代方法， 通过考虑替代方案来提高诊断准确性，但尚未 MEG数据收集和分析的标准化模式。

DESCRIPTION: (Verbatim from the Applicant's Abstract) The purpose of this project is to evaluate the contributions of Magnetoencephalography (MEG) to the surgical management of epilepsy. Specifically, we propose the following: First, to estimate the relative accuracy of MEG, as compared to that of surface and invasive electrophysiology, in identifying epileptogenic zones to be resected in patients with focal epilepsy. Second, to explore the possibility that identification of epileptogenic zones based on MEG data combined with data from other standard non-invasive diagnostic procedures and data from the Wada procedure may, in some cases, be sufficiently accurate to obviate the need for invasive electrophysiology. In addition, we propose to examine whether judgements of differential hemispheric involvement in language and memory derived from MEG data concur with those routinely derived from Wada procedure. Finally, incidental to addressing the above main questions, we will also address the question as to whether MEG influences the planning of invasive electrophysiological procedures and we will explore alternative ways of improving its diagnostic accuracy by considering alternative, not yet standardized modes of MEG data collection and analysis.