Console upgrade for 4.7T Imaging and Spectroscopy System

描述（由申请人提供）：我们是为数不多的研究小组之一， 高场系统（4.7T），致力于人体肌肉研究。我们 科学进步的记录确立了我们在研究 肌肉能量学、生理学和动物和人类肌肉的代谢， 开发人类疾病诊断方法的目标。新电脑， 软件和射频（RF）电子技术的进步将使广泛的 一系列新的实验方法，NIH资助的赠款在我们的实验室 和合作调查员的机会该申请要求资金， 购买一个新的控制台和射频电子设备，以取代80？的老式控制台。 这个过时的控制台阻碍了当前赠款的进展，因为 技术不足以推动新的进步。新的硬件和 软件将允许快速匀场、改进的信噪比、交错 用不同的细胞核进行采集，以及最先进的成像技术。我们依赖 主要是对表面线圈的使用，并在数字化仪有严重的局限性 用于复杂的、梯度增强的、成形脉冲的存储器和波形生成 序列的新控制台中的FASTMAP软件将使我们能够快速， 可重复地对通常偏离中心的人的肢体进行填隙。此次升级将 还允许容易地实施现有技术的灌注方法， 在我们的实验室开发的（FAWSETS），用于局部肌肉血流量测量。的 新的射频电子学将允许1H和31P的多核测量， 同时询问血流、ATP供应和需求，以及 新陈代谢.这些测量目前只能串行进行 我们的实验时间和受试者负担都增加了一倍。快速侦察机 成像检查表面线圈放置和最先进的回波平面 在收缩过程中绘制肌肉长度变化动态的成像并不 现在可能。新的控制台允许协调控制的机器人和 梯度将允许实施最先进的快速成像程序 所有项目都需要。这一升级将直接影响5个NIH资助的赠款 在放射学，并将协助在额外的3个国家卫生研究院赠款以外 包括2项资源赠款。

DESCRIPTION (provided by applicant): We are one of few research groups in the world with a high field system (4.7T) dedicated to human muscle research. Our track record of scientific advances establishes our preeminence for studies of muscle energetics, physiology, and metabolism in animal and human muscle with the goal of developing diagnostic methods for human diseases. New computer, software and radiofrequency (RF) electronic advances would make possible a wide range of new experimental approaches for NIH funded grants in our laboratory and for collaborating investigators. This application requests funds to purchase a new console and RF electronics to replace an 80?s vintage console. This out-dated console is hampering progress on current grants because of inadequate technology to push forward new advances. The new hardware and software will permit rapid shimming, improved signal to noise, interleaved acquisitions with different nuclei, and state-of-the-art imaging. We rely primarily on the use of surface coils and have serious limitations in digitizer memory and waveform generation for complex, gradient-enhanced, shaped-pulse sequences. The FASTMAP software in the new console will allow us to rapidly and reproducibly shim human limbs that are typically off center. This upgrade will also permit facile implementation of a state-of-the-art perfusion method, developed in our lab (FAWSETS), for local muscle blood flow measurements. The new RF electronics will permit multinuclear measurements of 1H and 31P for simultaneous interrogation of blood flow, ATP supply and demand, and metabolism. These measurements are currently possible only in serial experiments that double our experimental time and subject burden. Rapid scout imaging for checks on surface coil placement and state-of-the-art echo planar imaging to map the dynamics of muscle length changes during contraction are not possible now. The new console allowing coordinated control of the shims and gradients will permit implementation of state-of-the-art fast imaging programs needed for all projects. This upgrade will directly affect 5 NIH funded grants in Radiology and will assist in an additional 3 NIH grants outside the department, including 2 resource grants.