CORE--PEPTIDE AND OLIGONUCLEOTIDE LABORATORY

描述：（直接从申请中获取）肽/寡核苷酸核心通过以下活动为项目提供高响应的内部化学分析和合成服务资源和专业知识：(1)在一定范围内制备合成肽和类似物，然后记录其同质性；(2)多肽和生物合成产物的测序、质谱和氨基酸组成分析；(3)合成寡核苷酸的制备，作为筛选、杂交和定点诱变的探针；(4)开发和应用专门的化学程序，如交联、假体基团连接和“定制”净化方式；(5)在合成和纯化战略方面提供咨询意见和咨询，并向参与研究人员“实际”转让技术。

Description:(Taken directly from the application) The Peptide/ Oligonucleotide Core provides the Program Project with highly responsive, in-house resource for chemical-analytical and synthesis services and expertise through the following activities: (1) Preparation of synthetic peptides and analogs over a range of scales, followed by documentation of their homogeneity; (2) Performance of sequencing, mass spectroscopy, and amino acid compositional analyses of peptides and biosynthetic products; (3) Preparation of synthetic oligonucleotides for use as probes for screening, hybridization and site-directed mutagenesis; (4) Development and application of specialized chemical procedures such as cross linking, prosthetic group attachment and "customized" purification modalities; (5) Advice and consultation in synthesis and purification strategies and "hands-on" transfer of technologies to participating investigators.