CORE--ELECTRON PARAMAGNETIC RESONANCE FACILITY

描述（由申请人提供）：电子的目的 顺磁共振核心（EPR核心）在这项研究计划是提供 技术支持和咨询专业知识，以确保这些成功 需要EPR光谱的研究项目的方面，一氧化氮 检测和通过HPLC检测氧化还原活性化合物。 此外还 是EPR核心的一个目标，即开发新的方法和工具， 项目领导人追求的研究方向，目前没有 可能 EPR核心将提供设施和专业知识， 以下一般领域： 1.检测由正在研究的系统产生的自由基 各种项目，可能时直接EPR检测或使用 电子顺磁共振自旋捕获技术 2.一氧化氮的检测; 3.铁催化在自由基过程中的作用; 4.氧化还原活性化合物的HPLC检测; 5.脂质衍生物EPR自旋捕获的发展和认识 细胞的自由基。

DESCRIPTION (provided by applicant): The objective of the electron paramagnetic resonance core (EPR Core) in this research program is to provide the technical support and consultative expertise to ensure success for those aspects of the research projects that require EPR spectroscopy, nitric oxide detection, and detection of redox active compounds by HPLC. In addition, it is a goal of the EPR Core to develop new methods and tools that will permit the project leaders to pursue research directions that currently are not possible. The EPR Core will provide facilities and expertise to pursue experiments in the following general areas: 1. detection of free radicals generated by the systems being studied in the various projects, direct EPR detection when possible or detection using the EPR spin trapping technique; 2. the detection of nitric oxide; 3. the role of iron catalysis in free radical processes; 4. HPLC detection of redox active compounds; 5. development and understanding of the EPR spin trapping of lipid-derived radicals from cells.