XAS STRUCTURAL CHARACTERIZATION OF NO ADDUCTS OF HEMES

一氧化氮（NO）已被发现具有越来越多的 生物学作用包括作为神经递质。 以各种 这些功能，它是已知的，NO是结合血红素蛋白，但没有 有关此类性质的详细结构信息 约束力 这个项目的目的是利用XAS数据来了解 血红素蛋白NO加合物的几何和电子结构。 这种结构信息也将用于获得更好的 了解如何结合NO激活释放的 血红素蛋白中的NO-血红素基团。

Nitric oxide (NO) has been found to have an increasing number of biological roles including being a neurotransmitter. In a variety of these functions, it is known that NO is bound to heme proteins, but no detailed structural information is available on the nature of such binding. This project is aimed at using XAS data to understand the geometric and electronic structures of NO adducts of heme proteins. This structural information will also be used to gain a better understanding of how binding of NO activates the release of the NO-heme group from the heme protein.