Quantification of Regional coronary Blood Flow

描述(逐字摘自申请人的摘要)：最近的研究有 强调了常规冠状动脉造影术的局限性。这些 限制包括较大的观察者内和观察者间的可变性 冠状动脉狭窄病变的主观视觉分级结果。 此外，病理结果显示，两者之间缺乏相关性 根据冠状动脉造影术估计的冠状动脉狭窄的严重程度 在死后心脏中测量的狭窄病变的实际严重程度。因为. 标准冠状动脉造影术作为一种功能性测量方法的主要局限性 狭窄严重程度，如测量局部冠脉血流量 在心导管插入术中可获得。血液流动 测量将提供有价值的功能信息 常规冠状动脉造影术中获得的解剖数据。目的 本研究计划开发一种区域定量化技术。 首次通过分配算法与三维相结合的冠脉血流量 冠状动脉树重建及其在心脏手术中的应用 导尿室。更具体地说，目标是：(1)核实 局部心肌质量与动脉总和之间的线性关系 使用猪测量冠状血管树中任意点的远端分支长度 动物模型。(2)区域归一化假设的考察 冠脉血流量的测量可以利用第一次通过 结合动脉分支总和的分布分析技术 长度采用3-D重建冠状动脉树。(3)调查 归一化局部冠状动脉血流测量的假设可以是 用于评价不同大小血流灌注时冠状动脉狭窄程度 床。(4)实施区域冠脉血流测量 用于人体研究的心导管实验室中的技术。这个 这项研究的结果将提供改进的生理学方法 量化患者冠状动脉狭窄的严重程度。这种量化 这项技术可以用来测量患者的局部心肌灌注 接受标准的冠状动脉造影术。

DESCRIPTION (Verbatim from the Applicant's Abstract): Recent studies have emphasized the limitations of conventional coronary arteriography. These limitations include the large intraobserver and interobserver variability that result from subjective visual grading of coronary stenotic lesions. Furthermore, pathologic findings have shown a lack of correlation between the severity of coronary stenosis as estimated from coronary arteriogram and the actual severity of stenotic lesions measured in postmortem hearts. Because of the major limitations of standard coronary arteriography, a functional measure of stenosis severity such as measurement of regional coronary blood flow obtainable during cardiac catheterization is desirable. The blood flow measurement would provide valuable functional information in addition to the anatomical data obtained during routine coronary arteriography. The purpose of this research plan is to develop of a technique for quantification regional coronary blood flow by combining the first pass distribution algorithm with 3-D reconstruction of coronary artery tree and its implementation in the cardiac catheterization laboratory. More specifically, the aims are: (1) Verification of the linear relation between regional myocardial mass and the sum of arterial branch lengths distal to any point in the coronary vascular tree using a swine animal model. (2) Investigation of the hypothesis that normalized regional coronary blood flow measurement can be made utilizing the first pass distribution analysis technique in conjunction with the sum of arterial branch lengths using 3-D reconstruction of coronary artery tree. (3) Investigation of the hypothesis that normalized regional coronary blood flow measurement can be used to assess coronary artery stenosis severity in different size perfusion beds. (4) Implementation of the regional coronary blood flow measurement technique in the cardiac catheterization laboratory for human studies. The results of this research will provide improved physiological methods of quantitating coronary artery stenosis severity in patients. This quantification technique could be used to measure regional myocardial perfusion in patients undergoing standard coronary arteriography.