CORE--TISSUE PROCUREMENT

描述：(申请人描述)UAB在以下方面有丰富的经验 收集、加工、储存和供应各种各样的人体组织 以支持癌症和其他疾病的研究。纸巾是在 设施使用者所需要和要求的许多条件 包括新鲜的、冷冻的和加工过的石蜡。组织载玻片和其他 还提供组织学服务；在目前的赠款期间， 已经大大增加了需要组织切片代替组织切片的调查人员 以支持他们的研究。我们计划扩大规模 我们的服务是为希望 使用敏感的基于聚合酶链式反应的技术。在UAB协会获得的组织 医院被其工作人员冰冻地转移到外科病理学 获得诊断不需要的多余组织。外科病理学家 与UAB组织资源设施相关的评估所有 为质量和诊断准确性而提供的研究用组织。目前 组织被收集并在调查人员要求时提供给调查人员，我们 保持不活跃的肿瘤库。对于需要临床信息的研究 结果，我们建议建立一个具有良好特征的肿瘤标本库 和匹配的正常样本；这些样本中的等量可以提供给 研究人员未来将提供包括以下信息的临床数据 临床结果。UAB参与制定了一项全面的 通过整合有关组织资源的信息来支持组织资源的数据库 组织捐赠者、组织诊断和质量控制、组织处理和 组织的储存、研究人员对组织的需求和使用 研究人员。在1997年10月至1998年9月期间，该设施提供了 96名UAB调查人员，3289份人体组织标本和11326张幻灯片。 自1978年以来，我们的设施已经提供了大约59,448个组织标本， 块，并向UAB的225多名调查人员幻灯片。这些组织已经被 在总共720篇出版物和329篇摘要中使用。

Description: (Applicant's Description) UAB has extensive experience in collecting, processing, storing, and supplying a wide range of human tissues to support research in cancer and other diseases. Tissues are supplied in numerous conditions as needed and requested by the users of the facility including fresh, frozen, and paraffin processed. Tissue slides and other histology services also are provided; during the current grant period there has been a great increase in investigators requiring tissue sections in lieu of other forms of tissue to support their research. We are proposing to expand our services by offering microdissected specimens for investigators wishing to use sensitive PCR based technologies. Tissues obtained at the UAB associated hospitals are transferred on ice by its personnel to surgical pathology where excess tissues not required for diagnosis are obtained. Surgical pathologists associated with the UAB tissue resource facilities evaluate aliquots of all tissues supplied for research for quality and diagnostic accuracy. Currently tissues are collected and supplied to investigators when requested and we maintain no active tumor bank. For studies requiring information on clinical outcome, we propose to establish a bank of well characterized tumor specimens and matching normal specimens; aliquots of these could be supplied to investigators in the future with clinical data including information on clinical outcome. UAB has participated in the development of a comprehensive database that supports tissue resources by incorporating information on the tissue donor, tissue diagnosis and quality control, tissue processing and storage, investigator tissue requirements and usage of the tissues by researchers. Between October 1997 and September 1998, the facility provided 96 UAB investigators with 3289 human tissue specimens and 11,326 slides. Since 1978, our facility has provided approximately 59,448 tissue specimens, blocks, and slides to over 225 investigators at UAB. These tissues have been used in a total of 720 publications and 329 abstracts.