STATISTICAL METHODOLOGY IN ALZHEIMER'S DISEASE RESEARCH

描述（由申请人提供）：本提案的目的是 生物统计学家，神经流行病学家，神经心理学家， 人口统计学家、社会科学家、数据管理员和感兴趣的临床医生， 为讨论统计/分析目的的基础科学家 与AD研究中出现的关键问题相关的方法。这是 第二次这样的会议;第一次于1998年5月举行，非常成功， 吸引了在这一领域工作的定量科学家。 第二次会议的特邀会议将在这一成功的基础上再接再厉， 将涉及一些以前没有提到的问题。的具体目标 拟议的会议将涵盖以下主题领域： 1.与估计发病率相关的流行病学方法， AD和其他形式痴呆的患病率; 2.在系统性研究中遇到的概率和统计问题 与晚发性AD相关的基因的鉴定和多变量 用于分析单个神经元上的基因表达数据的方法; 3.纵向数据分析用于监测认知和行为 AD患者经历的衰退; 4.前瞻性临床试验设计中涉及的方法学问题 试验重点是疾病过程的早期发现/预防; 和 5.神经影像学解释中涉及的方法学问题 大脑的容量和功能。 此外，会议还将举办为期半天的方法研讨会， AD研究中的问题，重点是规划中涉及的问题， 开展预防AD的临床试验。会议将 包括两个关于相关主题投稿海报会议，其中一个 会议集中在学生和/或博士后研究。的 会议将对数据收集和标准化产生影响， 在ADCC进行的测量和国家一级的数据共享。

DESCRIPTION (Provided by applicant): The purpose of this proposal is to bring together biostatisticians, neuroepidemiologists, neuropsychologists, demographers, social scientists, data managers, and interested clinicians and basic scientists for the purpose of discussing statistical/analytical methodology associated with key issues arising in AD research. This is the second such conference; the first, held in May, 1998, was very successful in attracting a mix of quantitatively oriented scientists working in this area. The invited sessions of this second conference will build on that success, and will cover some issues not previously addressed. The specific aims of the proposed conference will cover the following topic areas: 1. epidemiological methodology associated with estimating the incidence and prevalence of AD and other forms of dementia; 2. probabilistic and statistical problems encountered in the systematic identification of genes associated with late onset AD and multivariate methods for the analysis of gene expression data on single neurons; 3. longitudinal data analysis used to monitor the cognitive and behavioral decline experienced by AD patients; 4. methodological issues involved in the design of prospective clinical trials with an emphasis on early detection/prevention of the disease process; and 5. methodological issues involved in the interpretation of neuroimages of the brain both volumetric and functional. In addition, the conference will host a half day workshop on methodologic issues in AD research with an emphasis on issues involved in the planning and implementing of clinical trials for the prevention of AD. The conference will include two contributed poster sessions on related topics with one of these sessions concentrating on student and/or post doctoral research. The conference will have implications for data collection and standardization of measurements made at ADCCs and for data sharing at the national level.