Neural Control of Breathing and Cardiovascular Function

描述(申请人提供)：此申请寻求支持，以培训呼吸和循环的神经控制的科学领袖。该计划将支持博士研究生，他们将根据本科生的表现和他们未来职业生涯的相关研究兴趣来选择。我们设计了一个综合培训计划，为这些未来的科学家做好准备，使他们能够将他们的技能应用于与呼吸的神经、行为和化学控制以及心血管功能相关的肺和心血管功能障碍问题。在过去的30年里，生理学和生物物理学的博士培训项目，特别是呼吸和心血管控制，已经从30多名学员中毕业，他们在美国各地从事研究和教学工作。在M.A.Haxhiu博士担任项目主任，C.Ovid Trouth博士和V.J.Massari博士担任项目联席主任，以及B.R.Coleman博士(系主任)的领导下，我们致力于加强对呼吸、呼吸道和循环的神经和激素控制的研究。这将通过以下方式实现：在现有研究计划的基础上，最大限度地发挥我们在神经科学、呼吸和心血管生理学方面的优势，并扩大与解剖学、生物化学、药理学、生物学和医学系现有研究人员的合作。我们在霍华德大学和合作密集研究机构的项目教员由知名科学家、经验丰富的培训师和NIH支持的研究人员组成，他们从事呼吸、呼吸道和心血管系统的神经和激素控制等相互关联的领域的工作，所有这些领域都包括基本的生物和临床组成部分。学生可以选择将他们的研究项目集中在呼吸控制、呼吸道功能或心血管系统方面。在这些相互关联的领域中提供经验丰富的导师和优秀的合作研究人员，以及这些领域之间的强大互动是这项建议的主要组成部分。“呼吸和循环的神经和荷尔蒙控制”系列研讨会将作为这两个领域的学员的核心，提供正式的课程和互动的“正在进行的研究”部分。研究生将有机会选择基础科学课程，并将接受手稿和赠款准备、教学和交流方面的培训。我们将与凯斯西储大学、约翰霍普金斯大学、梅奥医学院、密歇根大学、威斯康星大学和耶鲁大学的指定学院合作，提供充满活力的、专注的指导，以激励我们的学员发展坚实的学术生涯。

DESCRIPTION (provided by applicant): This application seeks support to train scientific leaders in neural control of breathing and circulation. This program will support Ph.D. graduate students that will be selected based on undergraduate performance and their relevant research interest for their future careers. We have designed an integrated training program to prepare these future scientists to apply their skills to problems in pulmonary and cardiovascular functional disorders in relation to neuronal, behavioral and chemical control of breathing, and cardiovascular functions. Over the last 30 years the Ph.D. training program in Physiology and Biophysics, with particular emphasis on respiratory and cardiovascular control has graduated more than 30 trainees who are in research and teaching throughout the U.S. Under the leadership of Dr. M. A. Haxhiu as Program Director, Drs. C. Ovid Trouth and V. J. Massari as Program Co-Directors, and Dr. B. R. Coleman, Departmental Chairperson, we are committed to focus and intensify research on neural and hormonal control of breathing, airways, and circulation. This will be accomplished by, building on current research programs and maximizing our strengths in neuroscience, respiration and cardiovascular physiology, and expanding existing collaborations with established investigators in the Departments of Anatomy, Biochemistry, Pharmacology, Biology and Medicine. Our program faculties at Howard University and at the Collaborative Intensive Research Institutions are comprised of well established scientists, experienced trainers, and NIH-supported investigators who are working in interrelated areas of neural and hormonal control of breathing, airways and the cardiovascular system, all of which encompass both basic biologic and clinical components. Students may choose to focus their research project in control of breathing, airway functions, or the cardiovascular system. The availability of experienced mentorship and outstanding Collaborative Research Faculty in these interrelated fields and the strong interaction between these fields are the major components of this proposal. A "Neural and Hormonal Control of Breathing and Circulation" Seminar Series will serve as a nucleus for the trainees from both fields by providing a formal curriculum and an interactive "research in progress" component. Graduate students will have the opportunity to select courses in the basic sciences and will be trained in manuscript and grant preparation, in teaching and communication. In collaboration with designated Faculty at Case Western Reserve University, Johns Hopkins University, Mayo Medical School, University of Michigan, University of Wisconsin, and Yale University, we will offer vigorous, focused mentorship that will motivate our trainees to develop solid academic careers.