BIOENGINEERING TRAINING CARDIOVASCULAR PATHOPHYSIOLOGY

描述 （改编自申请人的摘要）这一新的跨学科的建议， 心血管病理生理学生物工程培训补助金中心 最近成立的医学和工程研究所（IME）， 宾夕法尼亚大学的校际合作项目。 该提案 认识到有必要培训研究和临床研究员， 定量心血管病理生理学博士后水平 特别是因为它涉及分子生物医学工程， 细胞和组织水平。 假设驱动和设计驱动方法 知识将得到解决。 14个跨学科的基础和临床 生物工程和生物医学研究领域的科学家在IME内部相互交流 并与研究所的另外45名成员合作开展外展活动。 的 核心培训调查员接受了大约1000万美元（主要是 美国国立卫生研究院和国家科学基金会）的研究补助金支持，另有900万美元的补助金待定 支持. 八名培训教师是全职或副教授 与6位优秀的助理教授一起。 以其国， 最先进的研究实验室和核心实验室设施毗邻 医学院和工程学院。 备受关注的基准 跨学科研讨会系列（46讲座/年）将发展成为一个 完整的课程，和一个新的研究生课程在机械转导，将 补充目前的跨学科研究生课程提出一起 与密集的短期课程，和一个专门的实践责任科学 当然了 第一批拟培养3名博士前和3名博士后 每年递增1，直至第4年（稳定状态6/6）。 两 通常会提供多年的支持。 将挑选学员 由5名教师组成的指导委员会进行竞争性审查后， 仔细平衡，以代表赠款的跨学科性质。 培训生的选拔将根据学习成绩、 研究能力，并致力于跨学科的研究 心血管生物学 博士后和/或博士学员将 在培训期间，他们将获得很大的独立性。 博士前实习生将注册在研究生课程之一， 生物医学研究生组（基础科学，MSTP）或生物工程， 学院化学工程、机械工程研究生群体 工程系。 将要求或鼓励博士前学员 完成42小时的心血管生物学机械传导课程; 所有学员都必须完成研讨会/期刊俱乐部/讨论 当然了 IME与所有临床和基础部门广泛互动 两所学校。 对1）少数族裔征聘工作的反应，以及2） 研究的道德行为，都记录在案。 外部咨询委员会 被命名。

DESCRIPTION (Adapted from applicant's abstract) This new interdisciplinary proposal for a Bioengineering Training Grant in Cardiovascular Pathophysiology is center in the recently established Institute for Medicine and Engineering (IME), an interschool initiative at the University of Pennsylvania. The proposal recognizes the need to train research and clinical fellows at the pre- and postdoctoral levels in quantitative cardiovascular pathophysiology particularly as it pertains to biomedical engineering at the molecular, cellular, and tissue levels. Hypothesis-driven and design-driven approaches to knowledge will be addressed. Fourteen interdisciplinary basic and clinical scientists in bioengineering and biomedical research interact within the IME with collaborative outreach to an additional 45 Members of the Institute. The core training investigators are recipient of approximately $10m (principally NIH and NSF) research grant support, with an additional $9m pending grant support. Eight of the training faculty are Full or Associate Professors together with 6 outstanding Assistant Professors. The IME with its state-of- the-art research labs and core laboratory facilities is adjacent to both the School of Medicine and the School of Engineering. A well-attended benchmark Interdisciplinary Seminar Series (46 lectures/year) will be developed to a full course, and a new graduate course in mechanotransduction that will complement current interdisciplinary graduate courses is proposed together with intensive short-courses, and a specialized Practicing Responsible Science course. Three pre- and 3 postdoctoral trainees are proposed for the first year increasing by one each year up to the 4th year (steady state 6/6). Two years of support will normally be provided. Trainees will be selected following competitive review by a Steering Committee of 5 faculty that will be carefully balanced to represent the interdisciplinary nature of the grant. Trainee selections will be made on the basis of academic record, quality of research abilities, and commitment to research in interdisciplinary cardiovascular biology. Postdoctoral M.D. and/or Ph.D. trainees will be expected to develop significant independence during their training period. Predoctoral trainees will be registered in one of the graduate programs of the Biomedical Graduate Group (Basic science, MSTP) or the Bioengineering, Chemical Engineering, and Mechanical Engineering Graduate Groups of the School of Engineering. Predoctoral trainees will be required or encourage to complete a 42 hour course in mechanotransduction in cardiovascular biology; all trainees are required to complete the Seminars/Journal Club/Discussion course. The IME interacts extensively with all clinical and basic departments of both schools. Responsiveness to 1) minority recruitment efforts, and 2) ethical conduct of research, are documented. An External Advisory Committee is named.