Optical Detection of Intravenous Infiltration

描述(申请人提供)：在美国，大约80%的住院患者需要静脉注射治疗，50%的静脉输液管道失败是由于渗透、插管中的血块、静脉炎症反应或插管与静脉分离。静脉浸润性病变通常伴有导管尖端或插管部位的疼痛、红斑和肿胀。严重的渗出可能导致坏死，需要清创、植皮或截肢。及早发现渗入可防止可能需要手术矫正的严重事件的发生。该项目的长期目标是开发一种用于监测静脉输液故障的渗透传感器。第二阶段的研究设计包括开发先进的原型，改进算法，在动物模型和人体测量上对原型进行评估，调查其准确性和实用性，以及检查商业潜力。该项目的创新之处在于使用了一种光学方法，结合光纤光学和组织光学算法的先进发展，为静脉注射部位的非侵入性监测提供了一种手段。它将为接受静脉治疗的患者提供常规、自动、连续和实时的监测能力。

DESCRIPTION (provided by applicant): About 80% of hospital patients in the United States require IV therapy and 50% of IV lines fail due to infiltration, a clot in the cannula, an inflammatory response of the vein, or separation of the cannula from the vein. IV infiltration is usually accompanied by pain, erythema, and swelling at the cannula tip or the insertion site. Severe infiltration may lead to necrosis requiring skin debridement, skin grafting, or amputation. Early detection of infiltration prevents the occurrence of serious incidents that may require surgical correction. The long-term objective of this project is to develop an infiltration sensor for monitoring IV failures. The Phase II research design includes the development of an advanced prototype, improvement of algorithms, evaluation of the prototype on animal models and human measurements, investigation of its accuracy and utility, and the examination of the commercial potential. The innovation of this project lies in the use of an optical method coupled with the advanced development in fiber optics and algorithms for tissue optics to provide a means for noninvasive monitoring of the IV sites. It will provide routine, automated, continuous, and real-time monitoring capabilities for patients undergoing IV therapy.