Supplemental A&R Request for COBRE 1P20-RR-17695-01

描述(由申请人提供)： 本申请是对RFA RR-03-006的响应，RFA RR-03-006是生物医学研究卓越中心(COBRE)的改建和翻新以及设备的竞争性补充。这项名为“科布雷癌症研究发展中心的翻新和改建(A&R)”申请的资金，Grant 1 P20 RR17695-01，将用于升级和改造科罗西大楼四楼的一套办公室，用于科布雷行政和蛋白质组学核心。Coro大楼由罗德岛医院所有，距离罗德岛和妇幼医院约4个街区，距离肝脏研究中心约2个街区。持续的班车服务将核心大楼、医院和肝脏研究中心连接起来。A&R公司将为由P1、副主任、行政助理和秘书组成的Cobre行政核心和由主任、助理主任和研究助理组成的Cobre蛋白质组学核心提供办公场所。A&R还将为蛋白质组学核心提供实验室空间，为初级研究人员提供一个开发实验室，一个会议室、暗室、设备室、储藏室、通风柜和一个杂物室。本申请中描述的Cobre A&R空间总面积约为3500平方英尺。它就在整形外科研究小组新的基础研究实验室的正对面。科布雷A&R将与RIH在邻近空间资助的单独A&R进行协调。其中一部分将用于罗德岛医院研究支持实验室(RSL)的搬迁。研究支持实验室为科布雷中心和其他RIH研究人员提供各种研究支持服务，包括电子显微镜、高速FACS、图像分析和共聚焦显微镜。作为对Cobre癌症研究计划发展承诺的又一部分，罗德岛医院将翻新毗邻Cobre管理和蛋白质组学CERES的5000平方英尺的额外空间。这个空间将容纳国际癌症研究所、副主任和分子癌症发生实验室的其他成员，在国际癌症研究所的指导下，以及一个开放的实验室，用于未来的扩展。分子癌变实验室是目前罗德岛州最大的基础癌症研究小组。当上述联合翻修完成后，罗德岛医院将在其130年的历史上第一次在单一地点拥有一个真正的癌症研究中心。

DESCRIPTION (provided by applicant): This application is being submitted in response to RFA RR-03-006, Competitive Supplements to Center of Biomedical Research Excellence (COBRE) for alteration and renovation and equipment. The funds from this application entitled "Renovations and Alterations (A&R) for the COBRE Center for Cancer Research Development", Grant 1 P20 RR17695-01, will be used to upgrade and remodel a suite of offices on the fourth floor of the Coro West Building for the COBRE Administrative and Proteomics Cores. The Coro building is owned by Rhode island Hospital and is located approximately 4 blocks from Rhode island and Women and Infants Hospitals and 2 blocks from the Liver Research Center. Continuous shuttle service links the Core building, the Hospitals and the Liver Research Center. A&R will provide office space for the COBRE Administrative Core staffed by the P1, Deputy Director, Administrative Assistant and Secretary and for the COBRE Proteomics Core staffed by the Director, Assistant Director and Research Assistant. A&R will also produce laboratory space for the Proteomics Core, a developmental lab for junior investigators, a conference room, dark room, equipment room, storage space, fume hoods, and a utility room. The COBRE space for A&R described in this application totals approximately 3500 square feet. It is directly across from new basic research laboratories of the Orthopedics Research Group. The COBRE A&R will coordinate with separate A&R funded by RIH in adjacent space. Part of this will be used to relocate the Rhode Island Hospital Research Support Laboratories (RSL). Research Support Laboratories provide COBRE Center and other RIH Investigators with a variety of research support services including electron microscopy, high speed FACS, image analysis, and confocal microscopy. As still another part of its commitment to the development of the COBRE cancer research program, Rhode Island Hospital will renovate an 5000 additional sq ft of space adjacent to the COBRE Administrative and Proteomics Ceres. This space will house the laboratories of the PI, the Deputy Director, and other members of the Molecular Carcinogenesis Lab, under the Direction of the PI, and an open lab for future expansion. The Molecular Carcinogenesis Lab is currently the largest basic cancer research group in Rhode Island. When the above joint renovations are completed, Rhode Island Hospital will have for the first time in its 130 year history a true Cancer Research Center in a single site.