Improved head model for dipole analysis in children

描述（由申请人提供）： 偶极子源定位（DSL）是一种常用的分析技术，其中使用数学模型中的迭代计算机搜索算法来找到可以解释给定诱发反应的偶极子。DSL结果缺乏准确性的直接证据。由于模型中的参数不准确，有充分的理由预期结果不准确。其中一个不准确之处是关于头骨和头皮的弯曲。婴儿的问题更严重，因为颅骨电阻率必须随着颅骨钙化而改变。申请人已经模拟了估计关键DSL模型参数的方法，知道可以使不准确的模型准确。拟议的项目将使用记录的诱发反应在婴儿和儿童中测试这种方法。准确性的“金标准”将基于相同受试者的MRI记录。

DESCRIPTION (provided by applicant): DSL (Dipole-Source Localization) is a commonly used analysis technique in which an iterative computer search algorithm in a mathematical model is used to find dipoles that can explain a given evoked-response. DSL results lack any direct proof of accuracy. There are good reasons to expect inaccurate results, due to inaccurate parameters in the model. One of the inaccuracies concerns skull and scalp resistivities. The problem is worse with infants because the skull resistivity must change as the calvarium calcifies. The applicant has simulated a method of estimating critical DSL model parameters, knowing that an inaccurate model can be made accurate. The proposed project will test this method in infants and children, using recorded evoked responses. The "gold standard" for accuracy will be based on MRI recordings from the same subjects.