EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

描述(由申请人提供)： 莫特人类生长发育中心是底特律韦恩州立大学妇产科的一个研究中心。莫特中心的使命是推进生殖科学的基础和临床研究以及研究培训，包括妇女健康、生殖生物学、毒理学和围产期医学。2001年，美国国立卫生研究院的经费在全国妇产科中排名第六。30年来，目前的设施一直在履行其使命，解决未得到满足的国家妇女和儿童保健需求。为了在未来30年保持和加强国家在生殖健康和与怀孕相关的母胎研究和研究培训方面的领导作用，计划对莫特中心进行彻底翻新。 我们的5个阶段的现代化和扩建包括：1)一楼行政和会议设施(2001年3月完工)；2)全楼电力和暖通空调升级(2002年7月完工)； 3)NIH/NICHD围产期研究处的三楼实验室(2003年10月完工)；4)一楼和二楼的实验室、支助空间和教职员工办公室；一楼的临床研究中心(CRC)和研究生培训设施(目前的申请，计划于2004年完工)；5)Vivarum的升级(计划于2005年完成)。 本申请中提出的改进(第四阶段)将使莫特中心前三层的总研究空间增加41.3%，并为NIH资助的研究人员提供灵活、开放的实验室设施。大学、学校和密歇根州对前4个阶段的翻修承诺总额超过1,000万美元，远远超过本申请要求的2,467,800美元。

DESCRIPTION (provided by applicant): The C.S. Mott Center for Human Growth and Development is a research center in Wayne State University's Department of Obstetrics & Gynecology in Detroit. The Mott Center's mission is to advance basic and clinical research and research training in reproductive sciences, including women's health, reproductive biology, toxicology, and perinatal medicine. In 2001, the department ranked sixth in the nation in NIH funding among all Obstetrics & Gynecology departments. For 30 years, the current facility served its mission addressing unmet national health needs for women and children. To maintain and enhance national leadership role in reproductive health and pregnancy-related maternal-fetal research and research training over the next 30 years, plans are completely renovating the Mort Center. Our 5-phase modernization and expansion includes: 1) First floor administration and conference facilities (completed March 2001); 2) Building-wide power and HVAC upgrades (completed July 2002); 3) Third floor laboratories for the NIH/NICHD Perinatology Research Branch (completion due October, 2003); 4) Laboratories, support spaces and faculty offices on the ground and second floors; and a Clinical Research Center (CRC) and graduate training facilities on the first floor (current application, completion planned for 2004); and 5) Vivarium upgrade (planned for 2005). The improvements proposed in this application (for Phase IV) would increase total research space on the first three floors of the Mott Center by 41.3%, and provide flexible, open laboratory facilities for NIH-funded investigators. The total commitment on the part of the University, the School, and the State of Michigan to the first 4 phases of the renovation is over $10 million, far exceeding the $2,467,800 requested in this application.