NANOPOROUS INOGANIC BIOCAPSULES

描述(由申请人提供)：在过去的几年中，创建定义明确且可控的接口的能力一直是人们非常感兴趣的领域，特别是在生物医学领域。这项研究的目标是使用创新的材料合成策略来制造被动和主动的精密生物分离膜。他们特别感兴趣的是控制良好、稳定和均匀的纳米维膜的开发和表征，这些膜能够在血液分离过程中分离病毒和/或蛋白质，并阻断被包裹的异种细胞中的抗体和补体分子。在这种应用中，只有一个病毒或抗体分子通过膜泄漏就会危及整个系统。通过电场驱动阳极氧化铝或钛而形成的高比表面积圆柱形胶囊，其壁由纳米孔膜组成，可用于对纳米范围内的生物分子进行绝对过滤或排除。除了制造被动膜外，在该计划的赞助下，还将制造含有磁弹性元件的纳米孔生物胶囊。磁弹性元件使生物胶囊能够通过施加时变磁场来远程机械振动，并且他们相信最终允许一个人控制并通过膜进行运输。 拟议的研究项目将侧重于确定制备纳米多孔胶囊的最佳路线，并表征纳米多孔膜的材料/结构特性，同时关注膜的优化和作为生物过滤器的膜的功能。将研究用于细胞包裹/免疫隔离的被动纳米多孔生物胶囊和用于通过纳米孔膜的受控传输的磁弹性机械活性生物胶囊。

DESCRIPTION (provided by applicant): The ability to create well-defined and controlled interfaces has been an area of great interest over the last few years, particularly in the biomedical arena. The goal of this research is to use innovative materials synthesis strategies to create both passive, and active, precision bioseparation membranes. Of particular interest to them is the development and characterization of well-controlled, stable, and uniform nano-dimensional membranes capable of the separation of viruses and/or proteins during the blood fractionation process and the blocking of antibodies and complement molecules from encapsulated xenogeneic cells. In such applications, the leakage of just one virus or antibody molecule through the membrane will compromise the entire system. It is hypothesized that high surface area cylindrical capsules, the walls of which are comprised of nanoporous membranes, created via electric-field driven anodization of aluminum or titanium can be used for the absolute filtration or exclusion of biomolecules in the nanometer range. Beyond making passive membranes, under the program auspices, nanoporous biocapsules incorporating magnetoelastic elements will be fabricated. The magnetoelastic elements enable the biocapsule to be mechanically vibrated, remotely from a distance, by application of a time varying magnetic field facilitating, and they believe ultimately allowing one to control, transport through the membrane. The proposed research project will focus on defining optimal routes for the fabrication of nanoporous capsules and the characterization of the material/structural properties of the nanoporous membranes with attention to film optimization and the functionality of the membranes as biological filters. The application of passive nanoporous biocapsules for cellular encapsulation/immunoisolation and magnetoelastic mechanically-active biocapsules for controlled transport through the nanoporous membranes will be investigated.