Cumulative Risks and Asthma Morbidity in Urban Children

描述：(由申请人提供)哮喘是一种儿童慢性疾病，在美国来自低收入、城市和少数民族背景的儿童中有过多的表现(USDHHS，2000)。在这一人口结构范围内的儿童中，哮喘发病率和死亡率稳步上升，已被确认为一个重大的国家健康问题。NIH的一项主要研究重点是了解如何减少少数民族低收入儿童与更健康的白人儿童之间的健康差距。本研究将研究与城市贫困相关的多种风险的累积影响与非洲裔美国人、西班牙裔和非西班牙裔白人儿童(N=150，每个民族50个家庭)哮喘发病率之间的关系。具体地说，将利用累积风险指数(CRI)的开发和验证来调查风险模型是否能更好地预测城市儿童的哮喘发病率，该风险模型包括可能作为城市家庭风险(文化、背景、哮喘特有的)的多个维度的因素。城市和低收入的7-11岁哮喘儿童及其主要照顾者将参加以访谈为基础的评估。目前的研究将被整合到布朗医学院由NIH资助的哮喘差异研究中心(U01-HIO72438-01；首席研究员格雷戈里·弗里茨)。这项研究的结果将使未来的研究能够测试可能增强城市儿童哮喘相关功能的调节剂。

DESCRIPTION: (provided by applicant) Asthma is a childhood chronic illness that is over-represented in children from low income, urban, and ethnic minority backgrounds in the U.S. (USDHHS, 2000). The steady increase in asthma morbidity and mortality rates among children within this demographic profile has been identified as a significant national health concern. A major research priority for NIH is to understand how to decrease the health disparities between ethnic minority, low-income children and their healthier, white counterparts. The present study will examine the relationship between the cumulative impact of multiple risks associated with urban poverty and asthma morbidity in African-American, Hispanic, and non- Hispanic, white children (N= 150, 50 families in each ethnic group). Specifically, the development and validation of a Cumulative Risk Index (CRI) will be employed to investigate whether asthma morbidity in urban children is more adequately predicted by risk models that include multiple dimensions of factors that may function as risks (cultural, contextual, asthma-specific) for urban families. Urban and low-income, 7-11 year old children with asthma and their primary caregivers will participate in interview-based assessments. The current study will be integrated into an NIH funded Center for Asthma Disparities (U01-HIO72438-01; Principal Investigator Gregory Fritz) at Brown Medical School. Results from this study will enable future studies testing moderators that may enhance asthma-related functioning in urban children.