Virtual Reality Skills Training: Nicotine Dependence

描述（由申请人提供）：在I期试验中成功证明了虚拟现实提示暴露（VRCE）对吸烟的可行性后，我们提议基于传统的认知行为应对技能计划开发尼古丁依赖的虚拟现实技能训练（VRESS）治疗。虚拟现实将计算机图形与感官输入设备相结合，包括：跟踪设备，视觉头戴式显示器（HMD）和定向音频，旨在使参与者沉浸在计算机生成的虚拟环境中。尼古丁依赖的虚拟现实将在安全，保密和受控的实验室或办公室治疗环境中将VR元素与特定的药物线索，环境，药物相关的社交互动以及其他相关刺激相结合。视频图像和暴露于复杂的线索相结合的VEGFR2将扩展传统的线索暴露（反应性）方法，并将提供比传统治疗方法明显的优势。该项目的重点是开发七个额外的虚拟现实场景，结合计算机生成的和视频图像，描绘吸烟线索（例如香烟包装，烟灰缸，燃烧的香烟）和吸烟的社会互动（例如在社交环境中提供香烟，与吸烟者一起乘车，接近人们吸烟的建筑物入口）。此外，还将编写一份Vibrant治疗手册。将在一项针对吸烟者的临床试点研究中测试VEGFR2的可行性和有效性。从城市内城区哮喘诊所招募100名尼古丁依赖吸烟者，并将其随机分配至VELCADE+尼古丁替代疗法（NRT）或仅NRT（NRTO）组。一项为期10周的治疗试验将在治疗和随访（1、2、3和6个月）期间比较VELCADE +NRT与NRTO的香烟消耗量、co水平和戒烟率。此外，将使用VRCE在基线、第4周和第10周评估所有参与者的线索反应性（渴望和生理）。该项目的总体目标是为尼古丁依赖的吸烟者开发和测试VEGFR2戒烟方法。长期目标是开发和测试VEGFR2，并开发负担得起的交钥匙VEGFR2系统，该系统将在商业上提供给药物滥用项目，个人治疗师，医院和药物成瘾研究人员，用于尼古丁和其他滥用药物。

DESCRIPTION (provided by applicant): After successfully demonstrating the feasibility of virtual reality cue exposure (VRCE) for smoking in a phase I trial, we proposed to develop a virtual reality skills training (VRST) treatment for nicotine dependence based on traditional cognitive behavioral coping skills programs. VRST combines computer graphics with sensory input devices including: tracking devices, visual head mounted displays (HMD), and directional audio designed to immerse a participant in a computer-generated virtual environment. VRST for nicotine dependence will combine the elements of VR with specific drug cues, environments, drug related social interactions, and other associated stimuli in the safe, confidential and controlled lab or office treatment setting. VRST combining video images and exposure to complex cues will expand traditional cue-exposure (reactivity) approaches and will offer distinct advantages over traditional treatment approaches. This project focuses on the development of seven additional VRST scenarios combining both computer generated and video images depicting smoking cues (e.g. cigarette packages, ash trays, burning cigarette) and smoking social interactions (e.g. being offered a cigarette in a social context, riding in a car with a smoker, approaching a building entrance where people are smoking). In addition, a VRST treatment manual will be developed. The feasibility and efficacy of VRST will be tested in a clinical pilot study with cigarette smokers. One hundred nicotine dependent smokers recruited from and urban inner city asthma clinic and will be randomized to either VRST + nicotine replacement therapy (NRT) or NRT only (NRTO). A ten week treatment trial will compare VRST+NRT versus NRTO on cigarette consumption, co-levels, and cessation rates across treatment and follow up (1, 2, 3, & 6 months) time periods. In addition, all participants will be assessed for cue reactivity (craving and physiological) at baseline, week 4 and week 10 using VRCE. The overarching aim of this project is to develop and test VRST cessation approach for nicotine dependent cigarette smokers. The long-term goal is to develop and test the VRST, and develop affordable turnkey, VRST systems that will be commercially available to substance abuse programs, individual therapists, hospitals, and drug addiction researchers for nicotine and other drugs of abuse.