Core--Biostatistics and Array Analysis

描述(申请人提供)：生物统计和阵列分析核心负责(1)为项目和核心提供协调、集中的数据库管理支持，以及(2)全面的生物统计咨询、数据分析和报告。一个运作良好的核心对该方案项目的成功绝对至关重要，因为该提案中的所有五个项目都需要大量的生物统计学支持，而这种支持在其他地方是无法获得的。将生物统计支助集中在核心系统内将确保生物统计人员完全熟悉项目的所有方面。该计划项目还将从拥有一支专门从事微阵列实验分析的经验丰富的分析团队中受益匪浅。对于所有类型的研究数据(人、鼠标、微阵列等)，核心将以有序和及时的方式执行计划的分析。核心人员还可以帮助研究人员设计新的研究，并测试这些相关项目的交叉受精可能产生的新假设。最后，集中数据库管理对于提出微阵列实验的项目(项目1和项目4)以及对两个核心A都将是非常重要的 (病理学和组织资源)和核心C(动物处理和成像)。

DESCRIPTION (provided by applicant): The Biostatistics and Array Analysis Core is responsible for providing (1) coordinated, centralized database management support to Projects and Cores, and (2) comprehensive biostatistical consultation, data analysis, and reporting. A well functioning core will be absolutely critical to the success of the Program Project as all five projects in this proposal have substantial needs for biostatistical support and this support is not available elsewhere. Centralizing biostatistical support within the Core will ensure that the biostatisticians will be completely familiar with all aspects of the projects. The Program Project will also benefit greatly from having a dedicated and experienced team of analysts devoted to analysis of microarray experiments. For all types of research data (human, mouse, microarray, etc.), the Core will execute planned analyses in an orderly and timely way. Core personnel can also help the investigators design new studies and test new hypotheses that may arise by cross-fertilization of these related projects. Finally, centralized database management will be very important to projects proposing microarray experiments (Projects 1 and 4), and to both Core A (Pathology and Tissue Resource) and Core C (Animal Handling and Imaging).