CORE--Gene Regulation and Genetics Research Core

描述（由申请人提供）：基因调控和遗传学研究核心在其成员中确定了两个动态焦点小组。这些智库包括对环境在人类疾病机制中的作用有共同兴趣的科学家。成员可以参加一个或两个焦点小组。从焦点小组活动中产生的基于假设的研究已经成为来自不同学科的环境科学家的一个考验。作为基因调控和遗传学研究核心的结果，一个不同的专家科学家小组已经联合起来了解环境因素对基因调控、细胞信号和激素控制网络的影响，这些网络是人类心脏病、糖尿病和癌症发病机制的基础。对于环境健康科学领域以外的许多研究人员来说，如果没有基因调控和遗传学研究核心活动的好处以及EHS中心的成员资格，将环境成分与研究目标结合起来很可能不会形成。对于IEHS的教职员工来说，拥有EHS中心资源的额外优势，使基于机制的环境健康科学研究取得了巨大进步。本报告中提供的研究生产力的证据，确立了基因的有效性

Description (provided by applicant): The Gene Regulation and Genetics Research Core has identified two dynamic focus groups within its membership. These think tanks include scientists with common interests of the role of the environment on human disease mechanisms. Members may participate in one or both focus groups. The hypothesis-based research that has emerged from focus group activities has served as a crucible for environmental scientists from a variety of disciplines. As a consequence of the Gene Regulation and Genetics Research Core, a diverse group of expert scientists has joined forces to understand the effects of environmental factors on gene regulation, cell signaling, and hormonal control networks that underpin the pathogenesis of human heart disease, diabetes, and cancer. For many investigators outside the environmental health sciences field, incorporation of an environmental component with the research objectives would most likely not have taken shape without the benefit of the Gene Regulation and Genetics Research Core activities and EHS Center membership. For faculty members within the IEHS, having the added advantage of EHS Center resources has enabled quantum strides in mechanism-based environmental health sciences research. The evidence of research productivity that is provided in this report, establishes the validity of the Gene Regulation and Genetics Research Core as a functional nexus for intellectual scientific exchange and research synergy. The core has successfully drawn together scientists with diverse interdisciplinary backgrounds and has stimulated working collaborations among investigators who enjoy ready access to shared EHS Center core facilities. The technical and material support in the EHS Center facility cores has enabled core members to apply state-of-the-art approaches to well-integrated studies examining the impact of the environment on molecular and cellular processes.