Genetic Resources of the English Longit Study of Aging

描述（由申请人提供）：这是英国老龄化纵向研究（ELSA）遗传资源开发的修订申请。这笔拨款将侧重于基因（APOE和糖皮质激素受体基因），这些基因将提供有关社会地位和健康之间假设途径的信息。我们将重点关注三种因社会地位而异的结果，例如在较低的社会群体中风险增加；心血管状况（使用代谢综合征评分）、认知表现和身体表现。ELSA是一项关于健康、社会和经济问题及其在老龄化中的相互关系的队列研究，由国家老龄化研究所和英国政府资助。尽管ELSA以健康与退休研究为模型，但它特别适合于基因研究，因为除了丰富的社会、心理社会、经济和健康数据外，它还包括了美国比较研究中没有的生物学和表现数据。目前的资金提供到2005年9月的支助，包括在2004年收集血液样本。这个应用程序寻求一个研究增强来创建一个DNA存储库。丰富的社会心理和经济数据，加上良好的特征表型，将创建一个世界级的项目，探索候选多态性对社会下层群体加速衰老或增加年龄相关损伤水平的途径的贡献。对APOE基因的8个多态性的初步研究将提供一个充分研究的多态性对内表型的影响的估计，以及对研究较少和新标记的重要性的明确估计。此外，我们计划检测糖皮质激素受体基因的6个多态性，该基因是下丘脑-垂体-肾上腺轴的一部分。对这些基因的检查将使我们能够探索健康的社会决定因素的重要途径，并调查候选基因的贡献。该储存库将作为特定研究问题的基础，并将为集中于其他研究问题的其他研究提供遗传信息。

DESCRIPTION (provided by applicant): This is a revised application for the development of a genetic resource in the English Longitudinal Study of Ageing (ELSA). This grant will focus on genes (APOE and the glucocorticoid receptor gene) that will provide information on the hypothesized pathways between social position and health. We will focus on three outcomes that vary with social position such that there is increased risk in lower social groups; cardiovascular status (using metabolic syndrome score), cognitive performance and physical performance. ELSA is a cohort study of health, social and economic issues and their inter-relationships in aging, funded by the National Institute on Aging and the British Government. Although modeled on the Health and Retirement Study, ELSA is uniquely suited for genetic studies because alongside a wealth of social, psychosocial, economic and health data it crucially includes biological and performance data not available in comparative US studies. Current funding provides support until September 2005, including for collection of blood samples in 2004. This application seeks a study enhancement to create a DNA repository. The richness of the psychosocial and economic data, together with well characterized phenotypes will create a world class program exploring the contribution of candidate polymorphisms to the pathways involved in accelerated aging or increased levels of age related impairments in lower social groups. An initial program of examining 8 polymorphisms on the APOE gene will provide an estimate of the effect of well-studied polymorphisms on endophenotypes and definitive estimates of the importance of the less studied and new markers. Additionally, we plan to examine 6 polymorphisms in the glucocorticoid receptor gene, which is part of the hypothalamic-pituitary-adrenal axis. Examination of these genes will allow us to explore pathways important in social determinants of health and investigate the contribution of candidate genes. The repository will serve as the basis for the specified research questions and will provide genetic information for other studies concentrating on other research questions.