Conference-Safeguarding Adult/Pediatric Stem Cell Donors

描述(由申请人提供)： 这笔赠款是为了支持美国国立卫生研究院的R-13申请(对会议和科学会议的资助)，以举办一次为期一天半的非经常性会议，题为：保护成人和儿童干细胞捐赠者：基础科学、临床和伦理问题。研讨会将于2004年9月21日星期二(上午和下午)和9月22日星期三(仅上午)在马里兰州贝塞斯达NIH临床中心(10号楼)马苏尔礼堂举行。这次为期一天半的研讨会旨在解决与通过骨髓抽吸、外周血干细胞或脐带血采集提供干细胞的儿童和成人、有血缘关系和无血缘关系的同种异体捐赠者的安全有关的关键问题。这些问题的例子包括G-CSF动员的安全性和作用机制、骨髓抽吸造成肌肉骨骼和神经肌肉损伤的风险、外周血干细胞捐献者的低钙血症和中心导管并发症的风险，以及让相关捐赠者(特别是儿科捐赠者)暴露于G-CSF或其他动员剂的伦理问题。演讲者将包括成人和儿童干细胞移植领域的领军人物、伦理学家和输血医学专家。专题讨论会的目标1将是促进建立一个国家或国际捐赠者登记册数据库，该数据库将在捐献后多年跟踪匹配的无血缘关系捐赠者以及相关的同种异体捐赠者。登记处将仿照目前存在的ABMTR/IBMTR登记处的模式。目标2将鼓励和促进其他志愿机构标准(AABB、NMDP和FACT)的制定，旨在确保提高干细胞捐赠者的安全性。普遍认为应制定额外的捐赠者安全标准。本次研讨会将讨论制定此类标准的必要性，并推动这一进程。目标3将是在国家认可的期刊上发表研讨会的总结。

DESCRIPTION (provided by applicant): This grant is submitted in support of an R-13 application (Grant Support for Conferences and Scientific Meetings) to the NIH for a non-recurring one and one-half day conference entitled: Safeguarding Adult and Pediatric Stem Cell Donors: Basic Science, Clinical and Ethical Issues. The Symposium will be held on Tuesday September 21 (am and pm) and Wednesday September 22, 2004 (am only) and will be located in the Masur Auditorium NIH Clinical Center (Building 10), Bethesda, MD. This one and one-half-day Symposium will be designed to address key issues related to the safety of pediatric and adult, related and unrelated allogeneic donors providing stem cells via bone marrow aspiration, peripheral blood stem cell or cord blood collection. Examples of these issues include the safety and the mechanism of action of G-CSF mobilization, risks of musculoskeletal and neuromuscular damage from bone marrow aspiration, risk of hypocalcemia and central catheter complications in apheresis peripheral blood stem cell donors, and the ethics of exposing related donors (especially pediatric donors) to G-CSF or other mobilizing agents. Speakers will include leaders in the field of adult and pediatric stem cell transplantation, ethicists and transfusion medicine specialists. AIM 1 of the Symposium will be to facilitate development of a National or International Donor Registry database that would follow matched-unrelated as well as related allogeneic donors for years post donation. The Registry would be patterned after the ABMTR/IBMTR registry currently in existence. AIM 2 will be to encourage and facilitate the development of additional voluntary agency Standards (AABB, NMDP and FACT) aimed at ensuring increased stem cell donor safety. There is general consensus that additional donor safety Standards should be developed. This Symposium would address the need for such Standards and stimulate the process. AIM 3 will be to publish a summary of the Symposium in a nationally recognized Journal.