Biology of Hypoxia

描述（由申请人提供）：在本次会议结束后，与会者应能够：了解缺氧研究的最新和最重要的方面;欣赏目前对缺氧和血管生成之间关系的理解;了解氧传感和代谢功能之间的关系，特别是因为它涉及缺氧损伤期间的细胞和组织存活;了解目前对氧传感和缺氧反应在缺血性损伤中的作用的看法，如中风和心肌梗死;了解目前对缺氧诱导的分子传感和信号传导机制的看法;了解氧气传感在模式生物中的发育作用，并深入了解这些与人类生物学/病理学的关系。一个主要的目标将是把研究缺氧的不同小组聚集在一起。目前没有其他会议举行这种会议，我们认为，这将使交流与合作有前所未有的机会。在目前的文献中存在一些关于氧的机制和影响的争议;这次会议将把各种观点纳入同一背景，并将允许就这些问题达成共识。特别是，缺氧的影响，并在生理学，心脏病学和肿瘤学领域的研究;在这些领域的工作人员很少参加相同的论坛，然而，氧气反应的分子机制是揭示自己在这些学科所使用的许多实验系统是相似的。这次会议将使学生在培训的早期阶段，以了解和欣赏的串扰，可以而且应该存在不仅在不同领域，但将使学生获得目前存在的缺氧研究的问题的充分认识。虽然有专门的会议，出现在缺氧引起的疾病的一些问题，有没有其他学生将接触到的问题和方法在当前缺氧研究的多样性在本次会议上所代表的多样性的观点。

DESCRIPTION (provided by applicant): Upon completion of this conference, participants should be able to: understand the most current and important aspects of hypoxia research generally; appreciate current understanding of relationships between hypoxia and angiogenesis; understand the relationship between oxygen sensing and metabolic function, particularly as it relates to cell and tissue survival during hypoxic injury; appreciate current thinking on the role of oxygen sensing and hypoxic response in ischemic injuries, such as stroke and myocardial infarction; gain an understanding of current ideas about the molecular sensing and signaling mechanisms induced by hypoxia; understand the developmental roles oxygen sensing fulfill in model organisms, and gain insights into how these are relevant to human biology/pathology. A chief objective will be to bring the very disparate groups that work on hypoxia together. There is currently no other meeting where this occurs, and it will allow, we believe, unprecedented opportunities for cross-fertilization and collaboration to occur. A number of controversies on the mechanisms and effects of oxygen exist in the current literature; this meeting will bring the various points of view into the same setting and will allow a consensus on these issues to be built. In particular, hypoxia impacts and is studied in the fields of physiology, cardiology, and oncology; the workers in these fields rarely attend the same forums, and yet, the molecular mechanisms of oxygen response are revealing themselves to be similar in many of the experimental systems utilized by these disciplines. This meeting will allow students at an early stage of training to understand and appreciate the crosstalk that can and should exist not only within but among diverse fields, and will allow students to gain a full appreciation of the issues that currently exist in hypoxia research. Although there are meetings dedicated to a number of the issues that arise in hypoxia-induced diseases, there are no others where students will be exposed to a diversity of views of the problems and approaches in current hypoxia research with the diversity represented at this meeting.