Compact Multi-Wavelength Probe for Quantitative Tissue *

描述(由申请人提供)： 650-1000 nm波长范围的定量近红外组织光谱是一种灵敏的非侵入性工具，用于测量组织的光学特性，并将其与组织成分(如水、脂类、氧合血红蛋白和脱氧血红蛋白)相关联。特别是，频域和稳态宽带测量的使用在乳腺癌的检测、表征和治疗监测方面提供了相当大的前景。然而，目前，要获得准确的光谱信息，需要多个分立的二极管激光器和一个白光源，以便在单一光源和探测器位置进行测量。这需要一个复杂且耗电的系统，空间变化的多点测量越来越复杂。 这项研究旨在创造一种单芯片多波长光源，既可以取代分立二极管激光器，也可以取代白光光源。所提出的光源采用晶片键合技术来创建单片16通道多波长阵列。与温度调谐相结合，该光源可以覆盖整个650-1000 nm光谱，并可用于频域和稳态测量。阶段性！将演示4通道阵列的可行性。第二阶段将扩展到完整的波长覆盖，优化功率，并将新光源整合到功能光谱探测器中，该探测器将在组织模体、动物模型和人类受试者中进行评估。

DESCRIPTION (provided by applicant): Quantitative near infrared tissue spectroscopy in the 650-1000nm wavelength range is a sensitive non-invasive tool for measuring tissue optical properties, and correlating them with tissue components such as water, lipids, oxy-hemoglobin, and deoxy-hemoglobin. In particular, the use of both frequency domain and steady state broadband measurements offers considerable promise in the detection, characterization, and therapeutic monitoring of breast cancer. Currently, however, obtaining accurate spectral information requires multiple discrete diode lasers and a white light source for measurements at a single source and detector position. This requires a complex and power consumptive system, with increasing complexity for multi-point measurements of spatial variation. This research seeks to create a single-chip multi-wavelength source that can replace both discrete diode lasers and white light sources. The proposed source employs wafer bonding technology to create monolithic 16-channel multi-wavelength arrays. In conjunction with temperature tuning, this source can cover the entire 650-1000nm spectrum, and be used for both frequency domain and steady state measurements. Phase ! will demonstrate feasibility with a 4 channel array. Phase II will extend to complete wavelength coverage, optimize power, and incorporate the new source into a functional spectroscopic probe which will be evaluated in tissue phantoms, animal models, and human subjects.