CORE--Exposure and Biomarker

在目前的资助期内，暴露和生物标志物核心为中心的研究项目提供了关键的暴露监测、生物标志物分析和建模服务。这项研究在环境暴露在生长发育和哮喘中所起的作用方面产生了许多重要的新发现。在续文中，核心建议通过评估儿童发展过程中的暴露程度来建立和扩展这些发现。除了支持基于社区的哮喘和生长发育参与性研究（CBPR）项目的病因学目标外，核心还将继续开发和建立一个重要的数据库，研究曼哈顿北部和南布朗克斯地区多环芳烃（PAH）、非持久性农药（NPP）、环境烟草烟雾（ETS）、过敏原（蟑螂、老鼠、尘螨、猫和狗）、内毒素和霉菌暴露的分布和决定因素。将结果转化为社区外展和教育、风险评估和干预措施发展是一个中心目标。

Over the current funding period, the Exposure and Biomarker Core has provided key exposure monitoring, biomarker analysis, and modeling services for Center research projects. This research has resulted in a variety of important new findings regarding the roles played by environmental exposures in growth and development and asthma. In the continuation, the Core proposes to build on and extend these findings by assessing exposures over the time course of child development. In addition to supporting the etiologic aims of the community-based participatory research (CBPR) projects on Asthma and Growth and Development, the Core will continue to develop and build an important database on the distributions and determinants of exposures to polycyclic aromatic hydrocarbon (PAH), non-persistent pesticides (NPP), environmental tobacco smoke (ETS), allergens (cockroach, mouse, dust mite, cat and dog), endotoxins, and molds in northern Manhattan and the South Bronx. Translation of results for community outreach and education, risk assessment, and intervention development is a central aim. Specific aims of the Core are to: Aim 1. Characterize cohort exposures from pregnancy through the early childhood time periods to: PAH, NPP, ETS, allergens, endotoxins and molds. Aim 2. Characterize environmental exposures, genetic polymorphisms and nutritional levels to support the research being conducted by Center investigators on the modulation of risks by susceptibility factors (social adversity, genetic polymorphisms and nutritional deficits) as outlined in the CBRP projects on Asthma and Growth and Development. Aim 3. Characterize exposures and nutritional deficits to support the research on the translation of findings for community outreach and education, risk assessments, and development of strategies for exposure reduction as outlined in the activities of the Community Outreach Translation and Application Core (COTAC).